FZD8

Gene Symbol	FZD8
Entrez Gene	8325
Alt Symbol	FZ-8, hFZ8
Species	Human
Gene Type	protein-coding
Description	frizzled class receptor 8
Other Description	frizzled 8, seven transmembrane spanning receptor|frizzled family receptor 8|frizzled homolog 8|frizzled-8
Swissprots	Q9H461
Accessions	EAW85909 Q9H461 AB043703 BAB41064 AF086500 BC111845 AAI11846 NM_031866 NP_114072
Function	Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. {ECO:0000269|PubMed:11448771}.
Subcellular Location	Membrane; Multi-pass membrane protein. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with GOPC at the Golgi apparatus. {ECO:0000250}.
Tissue Specificity	Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle.
Top Pathways	Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Frizzled 8 peptide (684-694) - ab45837 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human Frizzled 8 protein fragment - ab152856 from Abcam Category Protein Source Wheat germ Species Human

FZD8 / Frizzled 8 Antibody Blocking Peptide - LS-E28992 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FZD8 / Frizzled 8 Antibody Blocking Peptide - LS-E28993 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FZD8 / Frizzled 8 Antibody Blocking Peptide - LS-E28994 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FZD8 / Frizzled 8 Antibody Blocking Peptide - LS-E25997 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FZD8 / Frizzled 8 Antibody Blocking Peptide - LS-E15182 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Frizzled-8 Protein - H00008325-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Frizzled 8 blocking peptide - GTX89473-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Recombinant Human Frizzled-8 Fc Chimera, CF - 6129-FZ-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

FZD8 Blocking Peptide - 33R-7027 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Frizzled 8 Peptide - AC21-0825-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

FZD8 / Frizzled-8 - H00008325-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FZD8 / Frizzled-8 - H00008325-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Frizzled 8 Peptide - 45-636P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant Human Frizzled Family Receptor 8, Fc-tagged - FZD8-597H from Creative Biomart Category Protein Source Chinese HamsterOvary cell line, CHO-derived

Recombinant Human FZD8, HIgG1 Fc-tagged therapeutic protein (Ipafricept) - FZD8-P012H from Creative Biomart Category Protein Species Human

Frizzled 8 Blocking Peptide - CBP2271 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

Frizzled-5/8 (W73) Peptide - BS2700P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Frizzled-8 (K528) Peptide - BS2715P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Frizzled-8 Fc Chimera Protein, CF - 6129-FZ from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Chinese Hamster Ovary cell line, CHO-derived Human Frizzled-8 (Ala25-Pro172) Accession # Q9H461 IEGRMD Human IgG 1 (Pro100-Lys330) N-terminus C-terminus Species Human

FZD8/frizzled 8, Peptide - MBS425467 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

Frizzled-8 Recombinant Protein Antigen - NBP1-87410PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

FZD8 Peptide, Human - M34GP05992H from Creative Peptides Category Peptide Source Synthetic. Species Human

Frizzled-8 (FZD8), Recombinant Protein - MBS7015423 from MyBioSource Category Protein Prices $1,455.00, $2,440.00, $3,650.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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