FZD8

Gene Symbol	FZD8
Entrez Gene	8325
Alt Symbol	FZ-8, hFZ8
Species	Human
Gene Type	protein-coding
Description	frizzled class receptor 8
Other Description	frizzled 8, seven transmembrane spanning receptor|frizzled family receptor 8|frizzled homolog 8|frizzled-8
Swissprots	Q9H461
Accessions	EAW85909 Q9H461 AB043703 BAB41064 AF086500 BC111845 AAI11846 NM_031866 NP_114072
Function	Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. {ECO:0000269|PubMed:11448771}.
Subcellular Location	Membrane; Multi-pass membrane protein. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with GOPC at the Golgi apparatus. {ECO:0000250}.
Tissue Specificity	Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle.
Top Pathways	Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Frizzled Homolog 8 ELISA Kit - abx052729 from Abbexa Category ELISA Kit

Frizzled-8, FZD8, Human, ELISA Kit - E1714h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Frizzled Homolog 8, FZD8, Human, ELISA Kit - E-EL-H1531 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Frizzled Homolog 8, FZD8, Rabbit, ELISA Kit - E-EL-RB1229 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Frizzled Homolog 8, FZD8, Chicken, ELISA Kit - E-EL-Ch0229 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Frizzled Homolog 8, FZD8, Porcine, ELISA Kit - E-EL-P1169 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Frizzled Homolog 8, FZD8, Monkey, ELISA Kit - E-EL-MK1241 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human FZD8 ELISA Kit - HF0273 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

FZD8, ELISA Kit - MBS2503687 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Human FZD8 is 0.469ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 0.781-50ng/mL

FZD8, ELISA Kit - MBS2511637 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

FZD8, ELISA Kit - MBS2501682 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

FZD8, ELISA Kit - MBS2509447 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

FZD8, ELISA Kit - MBS2504596 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

Human FZD8(Frizzled Homolog 8) ELISA Kit - E-EL-H1531 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Frizzied Homolog 8, ELISA Kit - MBS013636 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Frizzied Homolog 8, ELISA Kit - MBS019027 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Frizzied Homolog 8, ELISA Kit - MBS015188 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 5.0pg/ml. Range 31.2-1000pg/ml.

Frizzied Homolog 8, ELISA Kit - MBS035417 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Frizzied Homolog 8, ELISA Kit - MBS063580 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Frizzied Homolog 8, ELISA Kit - MBS015984 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Frizzied Homolog 8, ELISA Kit - MBS025725 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Frizzied Homolog 8, ELISA Kit - MBS054398 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Frizzied Homolog 8, ELISA Kit - MBS024979 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Frizzied Homolog 8, ELISA Kit - MBS037013 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Frizzied Homolog 8, ELISA Kit - MBS063907 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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