FZD8
| Gene Symbol | FZD8 |
|---|---|
| Entrez Gene | 8325 |
| Alt Symbol | FZ-8, hFZ8 |
| Species | Human |
| Gene Type | protein-coding |
| Description | frizzled class receptor 8 |
| Other Description | frizzled 8, seven transmembrane spanning receptor|frizzled family receptor 8|frizzled homolog 8|frizzled-8 |
| Swissprots | Q9H461 |
| Accessions | EAW85909 Q9H461 AB043703 BAB41064 AF086500 BC111845 AAI11846 NM_031866 NP_114072 |
| Function | Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. {ECO:0000269|PubMed:11448771}. |
| Subcellular Location | Membrane; Multi-pass membrane protein. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with GOPC at the Golgi apparatus. {ECO:0000250}. |
| Tissue Specificity | Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle. |
| Top Pathways | Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway |
frizzled-8 CRISPR/Cas9 KO Plasmid (h) - sc-408033 from Santa Cruz Biotechnology
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frizzled-8 HDR Plasmid (h) - sc-408033-HDR from Santa Cruz Biotechnology
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frizzled-8 Double Nickase Plasmid (h) - sc-408033-NIC from Santa Cruz Biotechnology
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frizzled-8 Double Nickase Plasmid (h2) - sc-408033-NIC-2 from Santa Cruz Biotechnology
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frizzled-8 CRISPR Activation Plasmid (h) - sc-408033-ACT from Santa Cruz Biotechnology
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frizzled-8 CRISPR Activation Plasmid (h2) - sc-408033-ACT-2 from Santa Cruz Biotechnology
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frizzled-8 Lentiviral Activation Particles (h) - sc-408033-LAC from Santa Cruz Biotechnology
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frizzled-8 Lentiviral Activation Particles (h2) - sc-408033-LAC-2 from Santa Cruz Biotechnology
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frizzled-8 siRNA (h) - sc-39992 from Santa Cruz Biotechnology
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frizzled-8 shRNA Plasmid (h) - sc-39992-SH from Santa Cruz Biotechnology
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frizzled-8 shRNA (h) Lentiviral Particles - sc-39992-V from Santa Cruz Biotechnology
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Frizzled-8 RNAi - H00008325-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN9028 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9028 from Sigma-Aldrich
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FZD8 siRNA (Human) - CRH5447 from Cohesion Biosciences
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FZD8 - MBS8234214 from MyBioSource
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shRNA set against Human FZD8 (NM_031866.2) - SHH298145 from Creative biogene
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Human FZD8 siRNA - orb265949 from Biorbyt
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FZD8 shRNA Plasmid (Human) - CHH5447 from Cohesion Biosciences
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FZD8 miRNA 3'UTR clone - MiUTR3H-08254 from Creative biogene
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