SLC22A1

Gene Symbol	SLC22A1
Entrez Gene	6580
Alt Symbol	HOCT1, OCT1, oct1_cds
Species	Human
Gene Type	protein-coding
Description	solute carrier family 22 (organic cation transporter), member 1
Other Description	organic cation transporter 1|solute carrier family 22 member 1
Swissprots	C9JSU6 O15245 Q9NQD4 A8K1H2 O15395 A6NFF3
Accessions	CAB95971 EAW47603 EAW47604 EAW47605 EAW47606 O15245 AK289887 BAF82576 AV684761 BC126364 AAI26365 HQ258293 ADR83047 U77086 AAB67703 X98332 CAA66977 XM_005267102 XP_005267159 XM_005267103 XP_005267160 XM_005267104 XP_005267161 XM_005267105 XP_005267162 XM_006715552 XP_006715615 XM_011536074 XP_011534376 NM_003057 NP_003048 NM_153187 NP_694857
Function	Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epit
Subcellular Location	Basolateral cell membrane {ECO:0000269|PubMed:16263091}; Multi-pass membrane protein {ECO:0000269|PubMed:16263091}.
Tissue Specificity	Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines. {ECO:0000269|PubMed:11388889, ECO:0000269|PubMed:9187257, ECO:0000269|PubMed:9260930}.
Top Pathways	Bile secretion, Choline metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

OCT1 (N-12) - sc-19809 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

OCT1 (X-21) - sc-133866 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-SLC22A1 antibody - ab118539 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SLC22A1 antibody - ab55916 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SLC22A1 antibody - ab123128 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SLC22A1 antibody - ab93491 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SLC22A1 antibody [2C5] - ab107246 from Abcam Prices $379.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2C5

Anti-SLC22A1 antibody [EPR3668(N)] - ab181022 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR3668(N)

Anti-SLC22A1 Antibody (aa510-539, APC) - LS-C217549 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC22A1 Antibody (aa510-539, AP) - LS-C217550 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC22A1 Antibody (aa510-539, FITC) - LS-C217553 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC22A1 Antibody (aa510-539, Biotin) - LS-C217551 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC22A1 Antibody (aa510-539, PE) - LS-C217555 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC22A1 Antibody (aa510-539, Azide-free, HRP) - LS-C217554 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC22A1 Antibody (C-Terminus) - LS-C31871 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SLC22A1 Antibody (aa510-539) - LS-C330144 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC22A1 Antibody (aa100-149) - LS-C31870 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SLC22A1 Antibody (aa491-540) - LS-C199955 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SLC22A1 Antibody (aa533-550) - LS-C313278 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SLC22A1 Antibody (aa511-539) - LS-C161155 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SLC22A1 Antibody (clone 2C5) IHC-plus™ - LS-B8937 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Mouse Clonality Monoclonal Clone 2C5

Anti-SLC22A1 Antibody (C-Terminus) - LS-C37850 from LifeSpan Bioscience Prices $385.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SLC22A1 Antibody (clone 609222) - LS-C144187 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 609222

OCT1 Antibody - NBP2-24677 from Novus Biologicals Prices $99.00, $229.00 Sizes 25 µg, 100 µg Host Rabbit Clonality Polyclonal

OCT1 Antibody - NBP2-24499 from Novus Biologicals Prices $99.00, $229.00 Sizes 25 µg, 100 µg Host Rabbit Clonality Polyclonal

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