SLC22A1
| Gene Symbol | SLC22A1 |
|---|---|
| Entrez Gene | 6580 |
| Alt Symbol | HOCT1, OCT1, oct1_cds |
| Species | Human |
| Gene Type | protein-coding |
| Description | solute carrier family 22 (organic cation transporter), member 1 |
| Other Description | organic cation transporter 1|solute carrier family 22 member 1 |
| Swissprots | C9JSU6 O15245 Q9NQD4 A8K1H2 O15395 A6NFF3 |
| Accessions | CAB95971 EAW47603 EAW47604 EAW47605 EAW47606 O15245 AK289887 BAF82576 AV684761 BC126364 AAI26365 HQ258293 ADR83047 U77086 AAB67703 X98332 CAA66977 XM_005267102 XP_005267159 XM_005267103 XP_005267160 XM_005267104 XP_005267161 XM_005267105 XP_005267162 XM_006715552 XP_006715615 XM_011536074 XP_011534376 NM_003057 NP_003048 NM_153187 NP_694857 |
| Function | Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epit |
| Subcellular Location | Basolateral cell membrane {ECO:0000269|PubMed:16263091}; Multi-pass membrane protein {ECO:0000269|PubMed:16263091}. |
| Tissue Specificity | Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines. {ECO:0000269|PubMed:11388889, ECO:0000269|PubMed:9187257, ECO:0000269|PubMed:9260930}. |
| Top Pathways | Bile secretion, Choline metabolism in cancer |
OCT1 CRISPR/Cas9 KO Plasmid (h) - sc-402232 from Santa Cruz Biotechnology
|
||||||||
OCT1 HDR Plasmid (h) - sc-402232-HDR from Santa Cruz Biotechnology
|
||||||||
OCT1 Double Nickase Plasmid (h) - sc-402232-NIC from Santa Cruz Biotechnology
|
||||||||
OCT1 Double Nickase Plasmid (h2) - sc-402232-NIC-2 from Santa Cruz Biotechnology
|
||||||||
OCT1 CRISPR Activation Plasmid (h) - sc-402232-ACT from Santa Cruz Biotechnology
|
||||||||
OCT1 CRISPR Activation Plasmid (h2) - sc-402232-ACT-2 from Santa Cruz Biotechnology
|
||||||||
OCT1 Lentiviral Activation Particles (h) - sc-402232-LAC from Santa Cruz Biotechnology
|
||||||||
OCT1 Lentiviral Activation Particles (h2) - sc-402232-LAC-2 from Santa Cruz Biotechnology
|
||||||||
OCT1 siRNA (h) - sc-42552 from Santa Cruz Biotechnology
|
||||||||
OCT1 shRNA Plasmid (h) - sc-42552-SH from Santa Cruz Biotechnology
|
||||||||
OCT1 shRNA (h) Lentiviral Particles - sc-42552-V from Santa Cruz Biotechnology
|
||||||||
SLC22A1 RNAi - H00006580-R02 from Novus Biologicals
|
||||||||
SLC22A1 RNAi - H00006580-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU086081 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN19454 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19454 from Sigma-Aldrich
|
||||||||
SLC22A1 siRNA (Human) - CRH4468 from Cohesion Biosciences
|
||||||||
SLC22A1 - MBS8206994 from MyBioSource
|
||||||||
shRNA set against Human SLC22A1 (NM_003057.2) - SHH409008 from Creative biogene
|
||||||||
shRNA set against Human SLC22A1(NM_153187.1) - SHL000734 from Creative biogene
|
||||||||
shRNA set against Human SLC22A1(NM_003057.2) - SHL000744 from Creative biogene
|
||||||||
shRNA set against Human SLC22A1(NM_153187.1) - SHL000745 from Creative biogene
|
||||||||
shRNA set against Human SLC22A1(NM_003057.2) - SHL000746 from Creative biogene
|
||||||||
shRNA set against Human SLC22A1(NM_153187.1) - SHL000747 from Creative biogene
|
||||||||
shRNA set against Human SLC22A1(NM_003057.2) - SHL000748 from Creative biogene
|