SLC22A1

Gene Symbol SLC22A1
Entrez Gene 6580
Alt Symbol HOCT1, OCT1, oct1_cds
Species Human
Gene Type protein-coding
Description solute carrier family 22 (organic cation transporter), member 1
Other Description organic cation transporter 1|solute carrier family 22 member 1
Swissprots C9JSU6 O15245 Q9NQD4 A8K1H2 O15395 A6NFF3
Accessions CAB95971 EAW47603 EAW47604 EAW47605 EAW47606 O15245 AK289887 BAF82576 AV684761 BC126364 AAI26365 HQ258293 ADR83047 U77086 AAB67703 X98332 CAA66977 XM_005267102 XP_005267159 XM_005267103 XP_005267160 XM_005267104 XP_005267161 XM_005267105 XP_005267162 XM_006715552 XP_006715615 XM_011536074 XP_011534376 NM_003057 NP_003048 NM_153187 NP_694857
Function Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epit
Subcellular Location Basolateral cell membrane {ECO:0000269|PubMed:16263091}; Multi-pass membrane protein {ECO:0000269|PubMed:16263091}.
Tissue Specificity Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines. {ECO:0000269|PubMed:11388889, ECO:0000269|PubMed:9187257, ECO:0000269|PubMed:9260930}.
Top Pathways Bile secretion, Choline metabolism in cancer

Human SLC22A1 (AAI26365) VersaClone cDNA - RDC0425 from R&D Systems

Prices $199.00
Sizes 10 µg
Species Human

Rat SLC22A1 (NP_036829) VersaClone cDNA - RDC0960 from R&D Systems

Prices $199.00
Sizes 10 µg
Species Rat

SLC22A1 - MBS1270898 from MyBioSource

Species Human
Accession BC126364

Human SLC22A1 transcript variant 1 Gene cDNA clone plasmid - HG16479-G from Sino Biological

Species Human
Accession NM_003057.2

Human SLC22A1 transcript variant 1 natural ORF mammalian expression plasmid - HG16479-UT from Sino Biological

Species Human
Accession NM_003057.2

human SLC22A1 ORF clone (NM_153187.1) - CDCH081194 from Creative biogene

Species Human

Human SLC22A1 ORF Clone (BC126364) - CDCS411122 from Creative biogene

Species Human
Accession O15245

Human SLC22A1 cDNA Clone(NM_153187.1) - CDFG009990 from Creative biogene

Species Human

Human SLC22A1 cDNA Clone(NM_003057.2) - CDFH017740 from Creative biogene

Species Human

human SLC22A1 ORF clone (NM_003057.2) - CDCH081196 from Creative biogene

Species Human
Search more