| Gene Symbol | SLC22A1 |
|---|---|
| Entrez Gene | 6580 |
| Alt Symbol | HOCT1, OCT1, oct1_cds |
| Species | Human |
| Gene Type | protein-coding |
| Description | solute carrier family 22 (organic cation transporter), member 1 |
| Other Description | organic cation transporter 1|solute carrier family 22 member 1 |
| Swissprots | C9JSU6 O15245 Q9NQD4 A8K1H2 O15395 A6NFF3 |
| Accessions | CAB95971 EAW47603 EAW47604 EAW47605 EAW47606 O15245 AK289887 BAF82576 AV684761 BC126364 AAI26365 HQ258293 ADR83047 U77086 AAB67703 X98332 CAA66977 XM_005267102 XP_005267159 XM_005267103 XP_005267160 XM_005267104 XP_005267161 XM_005267105 XP_005267162 XM_006715552 XP_006715615 XM_011536074 XP_011534376 NM_003057 NP_003048 NM_153187 NP_694857 |
| Function | Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epit |
| Subcellular Location | Basolateral cell membrane {ECO:0000269|PubMed:16263091}; Multi-pass membrane protein {ECO:0000269|PubMed:16263091}. |
| Tissue Specificity | Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines. {ECO:0000269|PubMed:11388889, ECO:0000269|PubMed:9187257, ECO:0000269|PubMed:9260930}. |
| Top Pathways | Bile secretion, Choline metabolism in cancer |
Human SLC22A1 peptide - ab111655 from Abcam
|
||||||||||
SLC22A1 Antibody Blocking Peptide - LS-E2829 from LifeSpan Bioscience
|
||||||||||
Recombinant Human SLC22A1 Protein - H00006580-G01-10ug from Novus Biologicals
|
||||||||||
SLC22A1-Antibody-C-term-Blocking-peptide - BP13944b from Abgent, a WuXi AppTec company
|
||||||||||
Oct1 Blocking Peptide - 33R-10467 from Fitzgerald
|
||||||||||
SLC22A1 Blocking Peptide - 33R-3892 from Fitzgerald
|
||||||||||
SLC22A1 Blocking Peptide - 33R-5413 from Fitzgerald
|
||||||||||
OCT1 Blocking Peptide - abx063106 from Abbexa
|
||||||||||
OCT1 Blocking Peptide - abx161186 from Abbexa
|
||||||||||
SLC22A1 fusion protein - ag20030 from Proteintech Group
|
||||||||||
SLC22A1 fusion protein - ag18806 from Proteintech Group
|
||||||||||
OCT1 Blocking Peptide - CBP3685 from Cohesion Biosciences
|
||||||||||
Recombinant Macropus eugenii POU domain, class 2, transcription factor 1(POU2F1 - CSB-YP632970MPE CSB-EP632970MPE CSB-BP632970MPE CSB-MP632970MPE from Cusabio
|
||||||||||
SLC22A1 Recombinant Protein Antigen - NBP1-89418PEP from Novus Biologicals
|
||||||||||
SLC22A1 Peptide, Human - M34GP14373H from Creative Peptides
|
||||||||||
Solute carrier family 22 member 1 (SLC22A1), Recombinant Protein - MBS1024453 from MyBioSource
|
||||||||||
Recombinant Human SLC22A1 Protein - SLC22A1-677H from Creative Biomart
|