SLC22A1

Gene Symbol SLC22A1
Entrez Gene 6580
Alt Symbol HOCT1, OCT1, oct1_cds
Species Human
Gene Type protein-coding
Description solute carrier family 22 (organic cation transporter), member 1
Other Description organic cation transporter 1|solute carrier family 22 member 1
Swissprots C9JSU6 O15245 Q9NQD4 A8K1H2 O15395 A6NFF3
Accessions CAB95971 EAW47603 EAW47604 EAW47605 EAW47606 O15245 AK289887 BAF82576 AV684761 BC126364 AAI26365 HQ258293 ADR83047 U77086 AAB67703 X98332 CAA66977 XM_005267102 XP_005267159 XM_005267103 XP_005267160 XM_005267104 XP_005267161 XM_005267105 XP_005267162 XM_006715552 XP_006715615 XM_011536074 XP_011534376 NM_003057 NP_003048 NM_153187 NP_694857
Function Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epit
Subcellular Location Basolateral cell membrane {ECO:0000269|PubMed:16263091}; Multi-pass membrane protein {ECO:0000269|PubMed:16263091}.
Tissue Specificity Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines. {ECO:0000269|PubMed:11388889, ECO:0000269|PubMed:9187257, ECO:0000269|PubMed:9260930}.
Top Pathways Bile secretion, Choline metabolism in cancer

Mouse/Human SLC22A1 ELISA Kit (DNA-Binding ELISA) - LS-F898 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate

solute carrier family 22 (organic cation transporter) , member 1, ELISA Kit - MBS9322957 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0ng/ml.
Range 3.12ng/ml-100ng/ml.

OCT1 TFact™ DNA-Binding ELISA - TFE-7120 from Assay Biotechnology

Category ELISA Kit
Prices $495.00, $990.00, $1,485.00
Sizes 1 kit, 2 kits, 3 kits

Human OCT1(Octamer-binding protein 1) ELISA Kit - E-EL-H1020 from Elabscience

Category ELISA Kit
Sensitivity 0.10 ng/mL
Range 0.16—10 ng/mL

OCT1 ELISA Kit - DEIA-XYA1354 from Creative Diagnostics

Category ELISA Kit

OCT1 ELISA Kit - DEIA-XYA1355 from Creative Diagnostics

Category ELISA Kit

Human SLC22A1 ELISA Kit - E096828 from Biobool

Category ELISA Kit

Human OCT1 (Octamer-binding protein 1) ELISA Kit - EKE60647 from Biomatik

Category ELISA Kit
Prices $609.00
Sizes 96 tests
Sensitivity 0.1 ng/mL
Range 0.16-10 ng/mL

OCT1 Colorimetric Cell-Based ELISA Kit - EKA50002 from Biomatik

Category ELISA Kit
Prices $399.00
Sizes 96 tests
Sensitivity At least 5000 cells/well
Range Qualitative
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