KPNA2

Gene Symbol	KPNA2
Entrez Gene	3838
Alt Symbol	IPOA1, QIP2, RCH1, SRP1alpha
Species	Human
Gene Type	protein-coding
Description	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Other Description	RAG cohort 1\|RAG cohort protein 1\|SRP1-alpha\|importin alpha 1\|importin alpha 2\|importin subunit alpha-1\|importin subunit alpha-2\|importin-alpha-P1\|karyopherin subunit alpha-2\|pendulin
Swissprots	P52292 Q9BRU5 Q53YE3 B9EJD6
Accessions	CAC83080 EAW89040 EAW89041 P52292 AK024833 AK058111 AK291954 BAF84643 BC005978 AAH05978 BC013257 BC034443 BC053343 AAH53343 BC067848 AAH67848 BC146905 AAI46906 BT006665 AAP35311 DQ890599 ABM92216 DQ893768 ABM84694 U09559 AAA65700 U28386 AAA69957 XM_011524783 XP_011523085 NM_002266 NP_002257
Function	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:7604027}. Nucleus {ECO:0000269\|PubMed:7604027}.
Tissue Specificity	Expressed ubiquitously.
Top Pathways	Influenza A

KPNA2 Antibody - 14372 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from HT-1080, NIH/3T3, and C6 cells using KPNA2 Antibody.

karyopherin α2 (1A6) - sc-101538 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rat
Clonality	Monoclonal

karyopherin α2 (1A6): sc-101538. Western blot analysis of karyopherin α2 expression in NIH/3T3 whole cell lysate.

karyopherin α2 (2G7) - sc-57009 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rat
Clonality	Monoclonal

karyopherin α2 (2G7): sc-57009. Western blot analysis of karyopherin α2 expression in HeLa (A) and MCF7 (B) nuclear extracts.

karyopherin α2 (B-9) - sc-55538 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

karyopherin α2 (B-9): sc-55538. Immuno?fluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and nuclear local?ization.

karyopherin α2 (C-20) - sc-6917 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

karyopherin α2 (C-20): sc-6917. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tumor showing cytoplasmic localization (A). Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and nuclear membrane localization (B).

karyopherin α2 (G-11) - sc-55537 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

karyopherin α2 (G-11): sc-55537. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

karyopherin α2 (H-50) - sc-25522 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

karyopherin α2 (H-50): sc-25522. Western blot analysis of karyopherin α2 expression in HeLa whole cell lysate.

Anti-KPNA2 antibody - ab84440 from Abcam

Prices	$382.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of KPNA2 in formalin fixed, paraffin embedded human metastatic lymph node tissue, using a 1/250 dilution of ab84440. Detection: DAB staining.

Anti-KPNA2 antibody - ab70160 from Abcam

Prices	$384.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-KPNA2 antibody (ab70160) at 0.04 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µgLane 5 : Mouse NIH3T3 whole cell lysate at 50 µg

Anti-KPNA2 antibody - ab99288 from Abcam

Prices	$378.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-KPNA2 antibody (ab99288) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 3 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 4 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate Lane 5 : MOLT4 (Human acute lymphoblastic leukemia cell line) Whole Cell Lysate Lane 6 : HeLa (Human epithelial carcinoma cell line) Nuclear LysateLane 7 : HepG2 (Human hepatocellular liver carcinoma cell line) Nuclear LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-KPNA2 antibody - ab37628 from Abcam

Prices	$378.00
Sizes	50 µg
Host	Chicken
Clonality	Polyclonal

Anti-KPNA2 antibody (ab37628) at 1/2000 dilution + E coli-derived fusion protein at 2.5 µgSecondaryGoat anti-IgY-HRP dilution at 1/1000 dilution

Anti-KPNA2 antibody - ab70609 from Abcam

Prices	$378.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human ovarian carcinoma tissues labelling KPNA2 with ab70609 at 1/1000 (1µg/ml). Detection: DAB.

Anti-KPNA2 antibody - ab6036 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-KPNA2 antibody - ab97580 from Abcam

Prices	$359.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-KPNA2 antibody (ab97580) at 1/500 dilutionLane 1 : HeLaS3 whole cell lysateLane 2 : HepG2 whole cell lysateLane 3 : Molt-4 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-KPNA2 antibody [2G7] - ab22534 from Abcam

Prices	$378.00
Sizes	50 µl
Host	Rat
Clonality	Monoclonal
Clone	2G7

Anti-KPNA2 antibody [EPR11716(B)] - ab170495 from Abcam

Prices	$379.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR11716(B)

Flow cytometric analysis of permeabilized 293T cells labeling KPNA2 with ab170495 at 1/10 dilution (red) or a rabbit IgG negative control (green).

Anti-KPNA2 antibody [EPR11717] - ab173295 from Abcam

Prices	$379.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR11717

All lanes : Anti-KPNA2 antibody [EPR11717] (ab173295) at 1/1000 dilutionLane 1 : Molt4 cell lysateLane 2 : 293T cell lysateLane 3 : HeLa cell lysateLysates/proteins at 10 µg per lane.

Anti-KPNA2 antibody [MM0769-21G39] - N-terminal - ab201615 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	MM0769-21G39

Anti-KPNA2 antibody - N-terminal - ab82313 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-KPNA2 antibody - N-terminal (ab82313) at 1/50 dilution + A2058 cell line lysate at 35 µg

Anti-KPNA2 / Importin Alpha 1 Antibody - LS-C48701 from LifeSpan Bioscience

Prices	$410.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KPNA2 / Importin Alpha 1 Antibody (aa1-132) - LS-C130325 from LifeSpan Bioscience

Prices	$605.00
Sizes	100 µg
Host	Sheep
Clonality	Polyclonal

Anti-KPNA2 / Importin Alpha 1 Antibody (aa2-132, clone 12K121) - LS-C182895 from LifeSpan Bioscience

Prices	$485.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	12K121

Anti-KPNA2 / Importin Alpha 1 Antibody (aa2-132, clone 11n120) - LS-C184836 from LifeSpan Bioscience

Prices	$465.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	11n120

Anti-KPNA2 / Importin Alpha 1 Antibody (aa116-515, clone 2G7) - LS-C82304 from LifeSpan Bioscience

Prices	$450.00
Sizes	50 µl
Host	Rat
Clonality	Monoclonal
Clone	2G7

Western blot of KPNA2 / Importin Alpha 1 antibody LS-C82304.

Anti-KPNA2 / Importin Alpha 1 Antibody (aa323-372) - LS-C102563 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

KPNA2 antibody LS-C102563 Western blot of Transfected 293T cell lysate.

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