KPNA2

Gene Symbol	KPNA2
Entrez Gene	3838
Alt Symbol	IPOA1, QIP2, RCH1, SRP1alpha
Species	Human
Gene Type	protein-coding
Description	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Other Description	RAG cohort 1|RAG cohort protein 1|SRP1-alpha|importin alpha 1|importin alpha 2|importin subunit alpha-1|importin subunit alpha-2|importin-alpha-P1|karyopherin subunit alpha-2|pendulin
Swissprots	P52292 Q9BRU5 Q53YE3 B9EJD6
Accessions	CAC83080 EAW89040 EAW89041 P52292 AK024833 AK058111 AK291954 BAF84643 BC005978 AAH05978 BC013257 BC034443 BC053343 AAH53343 BC067848 AAH67848 BC146905 AAI46906 BT006665 AAP35311 DQ890599 ABM92216 DQ893768 ABM84694 U09559 AAA65700 U28386 AAA69957 XM_011524783 XP_011523085 NM_002266 NP_002257
Function	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:7604027}. Nucleus {ECO:0000269|PubMed:7604027}.
Tissue Specificity	Expressed ubiquitously.
Top Pathways	Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KPNA2 full length protein - ab123205 from Abcam Category Protein Source E. coli Species Human

Human KPNA2 full length protein - ab40611 from Abcam Category Protein Source E. coli Species Human

Human KPNA2 full length protein - ab172174 from Abcam Category Protein Source E. coli Species Human

KPNA2 peptide - ab109889 from Abcam Category Peptide

KPNA2 / Importin Alpha 1 Antibody Blocking Peptide - LS-E19699 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KPNA2 / Importin Alpha 1 Antibody Blocking Peptide - LS-E25663 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KPNA2 / Importin Alpha 1 Antibody Blocking Peptide - LS-E31003 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Importin alpha 2/KPNA2 Recombinant Protein - H00003838-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Importin alpha 2/KPNA2 Partial Recombinant Protein - H00003838-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Importin alpha 2/KPNA2 Blocking Peptide - NBP1-76298PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant Human Importin alpha 2/KPNA2 Protein - NBP1-78888 from Novus Biologicals Category Protein Prices $269.00 Sizes 50 µg Source E. coli Species Human

KPNA2 Recombinant Protein - GTX48180-PRO from GeneTex Category Protein Prices $329.00 Sizes 50 μg Source E. coli Species Human

KPNA2 blocking peptide - GTX26036-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Human KPNA2 protein - orb49497 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human KPNA2 protein - orb168707 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli

Human KPNA1 protein - orb244328 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human Karyopherin Alpha 2 Protein - abx067600 from Abbexa Category Protein Source E.coli Species Human

KPNA2 Peptide - AC21-0493-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

KPNA2 / Importin alpha-2 (1-529, His-tag) - AR50214PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

KPNA2 / Importin alpha-2 (1-529, His-tag) - AR50214PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

KPNA2 / Importin alpha-2 - H00003838-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

KPNA2 / Importin alpha-2 - H00003838-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

KPNA2 / Importin alpha-2 - H00003838-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

KPNA2 / Importin alpha-2 - H00003838-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

KPNA2 / Importin alpha-2 control peptide - AP26275CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

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