| Gene Symbol | KPNA2 |
|---|---|
| Entrez Gene | 3838 |
| Alt Symbol | IPOA1, QIP2, RCH1, SRP1alpha |
| Species | Human |
| Gene Type | protein-coding |
| Description | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) |
| Other Description | RAG cohort 1|RAG cohort protein 1|SRP1-alpha|importin alpha 1|importin alpha 2|importin subunit alpha-1|importin subunit alpha-2|importin-alpha-P1|karyopherin subunit alpha-2|pendulin |
| Swissprots | P52292 Q9BRU5 Q53YE3 B9EJD6 |
| Accessions | CAC83080 EAW89040 EAW89041 P52292 AK024833 AK058111 AK291954 BAF84643 BC005978 AAH05978 BC013257 BC034443 BC053343 AAH53343 BC067848 AAH67848 BC146905 AAI46906 BT006665 AAP35311 DQ890599 ABM92216 DQ893768 ABM84694 U09559 AAA65700 U28386 AAA69957 XM_011524783 XP_011523085 NM_002266 NP_002257 |
| Function | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:7604027}. Nucleus {ECO:0000269|PubMed:7604027}. |
| Tissue Specificity | Expressed ubiquitously. |
| Top Pathways | Influenza A |