KPNA2

Gene Symbol	KPNA2
Entrez Gene	3838
Alt Symbol	IPOA1, QIP2, RCH1, SRP1alpha
Species	Human
Gene Type	protein-coding
Description	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Other Description	RAG cohort 1|RAG cohort protein 1|SRP1-alpha|importin alpha 1|importin alpha 2|importin subunit alpha-1|importin subunit alpha-2|importin-alpha-P1|karyopherin subunit alpha-2|pendulin
Swissprots	P52292 Q9BRU5 Q53YE3 B9EJD6
Accessions	CAC83080 EAW89040 EAW89041 P52292 AK024833 AK058111 AK291954 BAF84643 BC005978 AAH05978 BC013257 BC034443 BC053343 AAH53343 BC067848 AAH67848 BC146905 AAI46906 BT006665 AAP35311 DQ890599 ABM92216 DQ893768 ABM84694 U09559 AAA65700 U28386 AAA69957 XM_011524783 XP_011523085 NM_002266 NP_002257
Function	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:7604027}. Nucleus {ECO:0000269|PubMed:7604027}.
Tissue Specificity	Expressed ubiquitously.
Top Pathways	Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KPNA2 / Importin Alpha 1 ELISA Kit (Sandwich ELISA) - LS-F8290 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 125 pg/ml Range 125-8000 pg/ml

Importin subunit alpha-2, KPNA2, Human, ELISA Kit - E1138h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Karyopherin Alpha 2 (KPNa2), Human, ELISA Kit - SEE748Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 57pg/mL Range 125-8,000pg/mL

Karyopherin Alpha 2, ELISA Kit - MBS7221004 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Karyopherin Alpha 2, ELISA Kit - MBS7231777 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Karyopherin Alpha 2, ELISA Kit - MBS7235369 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Karyopherin Alpha 2, ELISA Kit - MBS7250781 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Karyopherin Alpha 2, ELISA Kit - MBS7202658 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Karyopherin Alpha 2, ELISA Kit - MBS7206315 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Karyopherin Alpha 2, ELISA Kit - MBS7223280 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Karyopherin Alpha 2 (KPNa2), ELISA Kit - MBS2019577 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 50pg/mL. Range 125-8000pg/mL

Karyopherin Alpha 2 (KPNa2), ELISA Kit - MBS9307386 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

karyopherin alpha 2 (RAG cohort 1, importin alpha 1) , ELISA Kit - MBS9340388 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Karyopherin Alpha 2 (KPNa2) - SEE748Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 50pg/mL. Range 125-8000pg/mL The standard curve concentrations used for the ELISA’s were 8000pg/mL, 4000pg/mL, 2000pg/mL, 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL

ELISA Kit for Karyopherin Alpha 2 (KPNa2) - SEE748Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 50pg/mL. Range 125-8000pg/mL The standard curve concentrations used for the ELISA's were 8000pg/mL, 4000pg/mL, 2000pg/mL, 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL

Human KPNA2 / Importin Alpha 1 ELISA Kit (Custom ELISA) - LS-F16148 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 125-8000 pg/ml

Mouse KPNA2 / Importin Alpha 1 ELISA Kit (Custom ELISA) - LS-F16149 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 125-8000 pg/ml

Human Importin subunit alpha-2 ELISA Kit - abx250558 from Abbexa Category ELISA Kit Range 0.312 ng/ml - 20 ng/ml

Karyopherin Alpha 2 (KPNa2), Human, ELISA Kit - DL-KPNa2-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 125-8,000 pg/m

Human KPNa2 ELISA Kit - abx574354 from Abbexa Category ELISA Kit Sensitivity 57 pg/ml Range 125 pg/ml - 8000 pg/ml

Human Importin subunit alpha-2 ELISA Kit - EKE53164 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.21 ng/mL Range 0.312-20 ng/mL

KPNA2 - EKH2588 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

Custom Human Importin alpha 2/KPNA2/SRP1-alpha ELISA - ELH-IMPTNa2-1 from RayBiotech Category ELISA Kit Prices $627.00, $1,128.60, $2,508.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human KPNA2 ELISA Kit - E021346 from Biobool Category ELISA Kit Sensitivity Typically less than 50pg/mL.

KPNA2 ELISA Kit (Human) (OKEH04634) - OKEH04634 from Aviva Systems Biology Category ELISA Kit Prices $596.00 Sizes 96 wells Sensitivity < 0.15 ng/mL Range 0.312 - 20 ng/mL

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