KPNA2
| Gene Symbol | KPNA2 |
|---|---|
| Entrez Gene | 3838 |
| Alt Symbol | IPOA1, QIP2, RCH1, SRP1alpha |
| Species | Human |
| Gene Type | protein-coding |
| Description | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) |
| Other Description | RAG cohort 1|RAG cohort protein 1|SRP1-alpha|importin alpha 1|importin alpha 2|importin subunit alpha-1|importin subunit alpha-2|importin-alpha-P1|karyopherin subunit alpha-2|pendulin |
| Swissprots | P52292 Q9BRU5 Q53YE3 B9EJD6 |
| Accessions | CAC83080 EAW89040 EAW89041 P52292 AK024833 AK058111 AK291954 BAF84643 BC005978 AAH05978 BC013257 BC034443 BC053343 AAH53343 BC067848 AAH67848 BC146905 AAI46906 BT006665 AAP35311 DQ890599 ABM92216 DQ893768 ABM84694 U09559 AAA65700 U28386 AAA69957 XM_011524783 XP_011523085 NM_002266 NP_002257 |
| Function | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:7604027}. Nucleus {ECO:0000269|PubMed:7604027}. |
| Tissue Specificity | Expressed ubiquitously. |
| Top Pathways | Influenza A |
karyopherin α2 CRISPR/Cas9 KO Plasmid (h) - sc-401484 from Santa Cruz Biotechnology
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karyopherin α2 HDR Plasmid (h) - sc-401484-HDR from Santa Cruz Biotechnology
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karyopherin α2 Double Nickase Plasmid (h) - sc-401484-NIC from Santa Cruz Biotechnology
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karyopherin α2 Double Nickase Plasmid (h2) - sc-401484-NIC-2 from Santa Cruz Biotechnology
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karyopherin α2 CRISPR Activation Plasmid (h) - sc-401484-ACT from Santa Cruz Biotechnology
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karyopherin α2 CRISPR Activation Plasmid (h2) - sc-401484-ACT-2 from Santa Cruz Biotechnology
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karyopherin α2 Lentiviral Activation Particles (h) - sc-401484-LAC from Santa Cruz Biotechnology
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karyopherin α2 Lentiviral Activation Particles (h2) - sc-401484-LAC-2 from Santa Cruz Biotechnology
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karyopherin α2 siRNA (h) - sc-35741 from Santa Cruz Biotechnology
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karyopherin α2 shRNA Plasmid (h) - sc-35741-SH from Santa Cruz Biotechnology
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karyopherin α2 shRNA (h) Lentiviral Particles - sc-35741-V from Santa Cruz Biotechnology
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Importin alpha 2/KPNA2 RNAi - H00003838-R01 from Novus Biologicals
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MISSION® esiRNA - EHU111181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11338 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11338 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01631 from Sigma-Aldrich
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KPNA2 siRNA (Human) - CRH2601 from Cohesion Biosciences
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shRNA set against Human KPNA2 (NM_002266.2) - SHH326999 from Creative biogene
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shRNA set against Human KPNA2(NM_002266.2) - SHL204858 from Creative biogene
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KPNA2 shRNA Plasmid (Human) - CHH2601 from Cohesion Biosciences
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KPNA2 miRNA 3'UTR clone - MiUTR1H-05423 from Creative biogene
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