UHRF2

Gene Symbol	UHRF2
Entrez Gene	115426
Alt Symbol	NIRF, RNF107, URF2
Species	Human
Gene Type	protein-coding
Description	ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase UHRF2|Np95-like ring finger protein|RING finger protein 107|np95/ICBP90-like RING finger protein|nuclear protein 97|nuclear zinc finger protein NP97|ubiquitin-like PHD and RING finger domain-containing protein 2|ubiquitin-like, containing PHD and RING finger domains, 2|ubiquitin-like-containing PHD and RING finger domains protein 2
Swissprots	Q5VYR1 Q659C8 Q5VYR3 Q96PU4 Q8TAG7
Accessions	EAW58743 Q96PU4 AB071698 BAB68317 AF274049 AAM33799 AK122730 BAG53694 AK308433 AL137728 CAH56383 AL833522 CAH10389 BC028397 AAH28397 BG709183 EU176286 ABW03737 EU176602 ABW03403 XM_011517703 XP_011516005 XM_011517704 XP_011516006 XM_011517705 XP_011516007 XM_011517706 XP_011516008 XR_428418 XR_428419 XR_428420 XR_428421 XR_929173 NM_152896 NP_690856 NR_046386
Function	E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131. {ECO:0000269|PubMed:12176013, ECO:0000269|PubMed:14741369, ECO:0000269|PubMed:15178429, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:21952639, ECO:0000269|PubMed:23404503}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00358, ECO:0000269|PubMed:12176013, ECO:0000269|PubMed:23404503}. Note=Enriched at pericentric heterochromatin (PH). This localization is dependent on the interaction with H3K9me3 (By similarity). {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

UHRF2 293T Cell Transient Overexpression Lysate(Denatured) - H00115426-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

UHRF2 overexpression lysate - LY407258 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

UHRF2 293 Cell Lysate - 404171 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

NIRF Overexpression Lysate (Denatured) - H00115426-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

NIRF Overexpression Lysate (Native) - NBL1-17604 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

NIRF (h): 293 Lysate - sc-170276 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

UHRF2 Over-expression Lysate Product - GWB-2486EC from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Panoply™ Human UHRF2 Knockdown Stable Cell Line - CSC-DC017071 from Creative biogene Category Cell Line Species Human

Search more