UHRF2

Gene Symbol	UHRF2
Entrez Gene	115426
Alt Symbol	NIRF, RNF107, URF2
Species	Human
Gene Type	protein-coding
Description	ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase UHRF2|Np95-like ring finger protein|RING finger protein 107|np95/ICBP90-like RING finger protein|nuclear protein 97|nuclear zinc finger protein NP97|ubiquitin-like PHD and RING finger domain-containing protein 2|ubiquitin-like, containing PHD and RING finger domains, 2|ubiquitin-like-containing PHD and RING finger domains protein 2
Swissprots	Q5VYR1 Q659C8 Q5VYR3 Q96PU4 Q8TAG7
Accessions	EAW58743 Q96PU4 AB071698 BAB68317 AF274049 AAM33799 AK122730 BAG53694 AK308433 AL137728 CAH56383 AL833522 CAH10389 BC028397 AAH28397 BG709183 EU176286 ABW03737 EU176602 ABW03403 XM_011517703 XP_011516005 XM_011517704 XP_011516006 XM_011517705 XP_011516007 XM_011517706 XP_011516008 XR_428418 XR_428419 XR_428420 XR_428421 XR_929173 NM_152896 NP_690856 NR_046386
Function	E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131. {ECO:0000269|PubMed:12176013, ECO:0000269|PubMed:14741369, ECO:0000269|PubMed:15178429, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:21952639, ECO:0000269|PubMed:23404503}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00358, ECO:0000269|PubMed:12176013, ECO:0000269|PubMed:23404503}. Note=Enriched at pericentric heterochromatin (PH). This localization is dependent on the interaction with H3K9me3 (By similarity). {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human NIRF full length protein - ab153579 from Abcam Category Protein Source Wheat germ Species Human

Human NIRF protein fragment - ab153580 from Abcam Category Protein Source Wheat germ Species Human

NIRF / UHRF2 Antibody Blocking Peptide - LS-E6069 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NIRF / UHRF2 Blocking Peptide - LS-E12387 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NIRF / UHRF2 Antibody Blocking Peptide - LS-E12304 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human NIRF Protein - H00115426-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human NIRF Protein - H00115426-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

UHRF2-Antibody-Center-Blocking-Peptide - BP18663c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IL17B protein - 30R-AI110 from Fitzgerald Category Protein Prices $225.00 Sizes 25 µg Source E.coli

UHRF2 - H00115426-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

UHRF2 - H00115426-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UHRF2 - H00115426-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human E3 ubiquitin-protein ligase UHRF2(UHRF2) ,partial - CSB-YP839395HU CSB-EP839395HU CSB-BP839395HU CSB-MP839395HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

UHRF2 - TP319579 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

NIRF Protein - NBP1-92183PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

NIRF Protein - NBP1-92182PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

UHRF2 Peptide, Human - M34GP17071H from Creative Peptides Category Peptide Source Synthetic. Species Human

E3 ubiquitin-protein ligase UHRF2 (UHRF2), partial, Recombinant Protein - MBS1451960 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Protein nirF (nirF), Recombinant Protein - MBS1437191 from MyBioSource Category Protein Prices $1,160.00, $1,160.00, $1,395.00, $1,395.00, $1,860.00, $1,860.00, $2,325.00, $2,325.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Pseudomonas

Protein nirF (nirF), Recombinant Protein - MBS1437806 from MyBioSource Category Protein Prices $1,160.00, $1,160.00, $1,390.00, $1,390.00, $1,860.00, $1,860.00, $2,325.00, $2,325.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Pseudomonas

Recombinant Human UHRF2 protein, MYC/DDK-tagged - UHRF2-10H from Creative Biomart Category Protein Source HEK293 Species Human

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