UHRF2

Gene Symbol	UHRF2
Entrez Gene	115426
Alt Symbol	NIRF, RNF107, URF2
Species	Human
Gene Type	protein-coding
Description	ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase UHRF2|Np95-like ring finger protein|RING finger protein 107|np95/ICBP90-like RING finger protein|nuclear protein 97|nuclear zinc finger protein NP97|ubiquitin-like PHD and RING finger domain-containing protein 2|ubiquitin-like, containing PHD and RING finger domains, 2|ubiquitin-like-containing PHD and RING finger domains protein 2
Swissprots	Q5VYR1 Q659C8 Q5VYR3 Q96PU4 Q8TAG7
Accessions	EAW58743 Q96PU4 AB071698 BAB68317 AF274049 AAM33799 AK122730 BAG53694 AK308433 AL137728 CAH56383 AL833522 CAH10389 BC028397 AAH28397 BG709183 EU176286 ABW03737 EU176602 ABW03403 XM_011517703 XP_011516005 XM_011517704 XP_011516006 XM_011517705 XP_011516007 XM_011517706 XP_011516008 XR_428418 XR_428419 XR_428420 XR_428421 XR_929173 NM_152896 NP_690856 NR_046386
Function	E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131. {ECO:0000269|PubMed:12176013, ECO:0000269|PubMed:14741369, ECO:0000269|PubMed:15178429, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:21952639, ECO:0000269|PubMed:23404503}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00358, ECO:0000269|PubMed:12176013, ECO:0000269|PubMed:23404503}. Note=Enriched at pericentric heterochromatin (PH). This localization is dependent on the interaction with H3K9me3 (By similarity). {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

NIRF CRISPR/Cas9 KO Plasmid (h) - sc-403908 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

NIRF HDR Plasmid (h) - sc-403908-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NIRF Double Nickase Plasmid (h) - sc-403908-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NIRF Double Nickase Plasmid (h2) - sc-403908-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NIRF CRISPR Activation Plasmid (h) - sc-403908-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

NIRF CRISPR Activation Plasmid (h2) - sc-403908-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

NIRF Lentiviral Activation Particles (h) - sc-403908-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NIRF Lentiviral Activation Particles (h2) - sc-403908-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NIRF siRNA (h) - sc-72380 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NIRF shRNA Plasmid (h) - sc-72380-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NIRF shRNA (h) Lentiviral Particles - sc-72380-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NIRF RNAi - H00115426-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

NIRF RNAi - H00115426-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

NIRF RNAi - H00115426-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU113861 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22481 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22481 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

UHRF2 siRNA (Human) - CRJ4449 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

UHRF2 - MBS8226675 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

NIRF CRISPR/Cas9 KO Plasmid (h2) - sc-403908-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

NIRF HDR Plasmid (h2) - sc-403908-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human UHRF2 (NM_152896.2) - SHH440333 from Creative biogene Category siRNA Species Reactivities Human

UHRF2 shRNA Plasmid (Human) - CHJ4449 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

UHRF2 miRNA 3'UTR clone - MiUTR3H-16503 from Creative biogene Species Reactivities Human

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