FSTL3

Gene Symbol FSTL3
Entrez Gene 10272
Alt Symbol FLRG, FSRP
Species Human
Gene Type protein-coding
Description follistatin-like 3 (secreted glycoprotein)
Other Description follistatin-like protein 3|follistatin-related gene protein|follistatin-related protein 3
Swissprots A8K7E3 O95633
Accessions EAW61165 EAW61166 O95633 AK291958 BAF84647 AK311521 AK311566 AK313341 AL050194 AY358917 AAQ89276 BC005839 AAH05839 BC033119 BQ319646 BX439786 U76702 AAC64321 NM_005860 NP_005851
Function Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. {ECO:0000269|PubMed:11948405, ECO:0000269|PubMed:15451575, ECO:0000269|PubMed:15574124, ECO:0000269|PubMed:16336961, ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:17878677}.
Subcellular Location Isoform 1: Secreted.
Tissue Specificity Expressed in a wide range of tissues. {ECO:0000269|PubMed:11459787}.

FLRG (H-74) - sc-367324 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FLRG (H-74): sc-367324. Western blot analysis of FLRG expression in HeLa (A), A549 (B), DU 145 (C), Hep G2 (D), SK-OV-3 (E) and A-431 (F) whole cell lysates.

FLRG (N-18) - sc-21302 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FLRG (N-18): sc-21302. Western blot analysis of FLRG expression in human skeletal muscle tissue extract.

Anti-FSTL3 antibody - ab65202 from Abcam

Prices $242.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FSTL3 antibody - C-terminal - ab170680 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-FSTL3 antibody - C-terminal (ab170680) at 1/100 dilution + CEM cell lysate at 35 µg

Anti-FSTL3 / FLRG Antibody (aa228-258, Biotin) - LS-C207055 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FSTL3 / FLRG Antibody (aa228-258, AP) - LS-C207053 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FSTL3 / FLRG Antibody (aa228-258, FITC) - LS-C207056 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FSTL3 / FLRG Antibody (aa228-258, APC) - LS-C207054 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FSTL3 / FLRG Antibody (aa228-258, Azide-free, HRP) - LS-C207057 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FSTL3 / FLRG Antibody (aa228-258, PE) - LS-C207058 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FSTL3 / FLRG Antibody (aa228-258) - LS-C329555 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FSTL3 / FLRG Antibody (aa145-159) - LS-C313049 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of FSTL3 / FLRG antibody. Recombinant Protein Detection Source:. E.coli derived -recombinant Human FSTL3, 39.2KD. (162aa tag+ L52-P251). Lane 1: Recombinant Human FSTL3 Protein 10ng. Lane 2: Recombinant Human FSTL3 Protein 5ng.

Anti-FSTL3 / FLRG Antibody (aa229-258) - LS-C166265 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
FSTL3 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human testis tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Follistatin-related Gene Protein/FLRG/Fstl3 Antibody - AF1288 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Recombinant Human Follistatin-related Gene Protein/FLRG (Catalog # 1288-F3) inhibits Recombinant Human/Mouse/Rat Activin A (Catalog # 338-AC) induced hemoglobin expression in the K562 human chronic myelogenous leukemia cell line in a dose-dependent manner (orange line), as measured by the psuedoperoxidase activity. Inhibition of Recombinant Human/Mouse/Rat Activin A (7.5 ng/mL) activity elicited by Recombinant Human Follistatin‑related Gene Protein/FLRG (0.1 µg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human Follistatin-related Gene Protein/FLRG Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1288). The ND50 is typically 1‑4 µg/mL.

Follistatin-related Gene Protein/FLRG/Fstl3 Antibody - NBP2-32034 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Follistatin-related Gene Protein/FLRG/Fstl3 Antibody [Biotin] - BAF1288 from Novus Biologicals

Prices $390.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-FSTL3 antibody produced in rabbit - HPA045378 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-FSTL3: <B>Cat. No. HPA045378</B>: Immunohistochemical staining of Human kidney shows strong cytoplasmic positivity in cells in tubules.

Anti-FSTL3 (66-80) antibody produced in rabbit - F8056 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-FSTL3 (66-80): <B>Cat. No. F8056</B>: Immunofluorescence of HUVEC cells using FSTL3 (66-80), Cat. No. F8056 (red) at a 1:100 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

ANTI-FSTL3 (C-TERM) antibody produced in rabbit - SAB1303578 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>FSTL3 (C-term): <B>Cat. No. SAB1303578</B>: FSTL3 in Human testis tissue with FSTL3 antibody (C-term) at 10 μg/mL.

FSTL3-Antibody-C-term - AP12300b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
FSTL3 Antibody (C-term) (Cat. #AP12300b) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the FSTL3 antibody detected the FSTL3 protein (arrow).

Anti-FSTL3-antibody - AP50917 from Abgent, a WuXi AppTec company

Prices $295.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysates from HepG2 cell line and human placenta tissue(from left to right), using Anti-FSTL3 antibody (bs-16188R). bs-16188R was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysates at 20ug per lane.

FSTL3 antibody - GTX12198 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Anti-FSTL3 antibody used in Western blot. GTX12198

FSTL3 Antibody - C-terminal region (OAAB08557) - OAAB08557 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

Mouse Follistatin-related Gene Protein/ FLRG Antibody - AF1255 from R&D Systems

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Follistatin-related Gene Protein/FLRG Inhibition of Activin A-induced Hemoglobin Expression and Neutralization by Mouse Follistatin-related Gene Protein/FLRG Antibody. Recombinant Mouse Follistatin-related Gene Protein/FLRG (Catalog # 1255-F3 ) inhibits Recombinant Human/Mouse/Rat Activin A (Catalog # 338-AC ) induced hemoglobin expression in the K562 human chronic myelogenous leukemia cell line in a dose-dependent manner (orange line), as measured by the psuedoperoxidase assay. Inhibition of Recombinant Human/Mouse/Rat Activin A (7.5 ng/mL) activity elicited by Recombinant Mouse Follistatin-related Gene Protein/FLRG (0.1 µg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse Follistatin-related Gene Protein/FLRG Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1255). The ND 50 is typically 3-12 µg/mL.

Mouse FLRG Affinity Purified Polyclonal Ab, Goat IgG - AF1255-SP from R&D Systems

Host Goat
Clonality Polyclonal
Follistatin-related Gene Protein/FLRG Inhibition of Activin A-induced Hemoglobin Expression and Neutralization by Mouse Follistatin-related Gene Protein/FLRG Antibody. Recombinant Mouse Follistatin-related Gene Protein/FLRG (Catalog # 1255-F3) inhibits Recombinant Human/Mouse/Rat Activin A (Catalog # 338-AC) induced hemoglobin expression in the K562 human chronic myelogenous leukemia cell line in a dose-dependent manner (orange line), as measured by the psuedoperoxidase assay. Inhibition of Recombinant Human/Mouse/Rat Activin A (7.5 ng/mL) activity elicited by Recombinant Mouse Follistatin-related Gene Protein/FLRG (0.1 µg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse Follistatin-related Gene Protein/FLRG Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1255). The ND50 is typically 3‑12 µg/mL.
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