Gene Symbol | FSTL3 |
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Entrez Gene | 10272 |
Alt Symbol | FLRG, FSRP |
Species | Human |
Gene Type | protein-coding |
Description | follistatin-like 3 (secreted glycoprotein) |
Other Description | follistatin-like protein 3|follistatin-related gene protein|follistatin-related protein 3 |
Swissprots | A8K7E3 O95633 |
Accessions | EAW61165 EAW61166 O95633 AK291958 BAF84647 AK311521 AK311566 AK313341 AL050194 AY358917 AAQ89276 BC005839 AAH05839 BC033119 BQ319646 BX439786 U76702 AAC64321 NM_005860 NP_005851 |
Function | Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. {ECO:0000269|PubMed:11948405, ECO:0000269|PubMed:15451575, ECO:0000269|PubMed:15574124, ECO:0000269|PubMed:16336961, ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:17878677}. |
Subcellular Location | Isoform 1: Secreted. |
Tissue Specificity | Expressed in a wide range of tissues. {ECO:0000269|PubMed:11459787}. |
Human FSTL3 peptide - ab66734 from Abcam
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Human FSTL3 protein fragment - ab160921 from Abcam
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FSTL3 / FLRG Antibody Blocking Peptide - LS-E1561 from LifeSpan Bioscience
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Recombinant Human Follistatin-related Gene Protein/FLRG/Fstl3 Protein - H00010272-Q01 from Novus Biologicals
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FSTL3-Antibody-C-term-Blocking-peptide - BP12300b from Abgent, a WuXi AppTec company
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Recombinant Human FLRG - 1288-F3-025 from R&D Systems
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Recombinant Human FLRG, CF - 1288-F3-025/CF from R&D Systems
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Follistatin-related protein 3 - H00010272-Q01-10 from Acris Antibodies
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Follistatin-related protein 3 - H00010272-Q01-25 from Acris Antibodies
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FSTL3 fusion protein - ag13124 from Proteintech Group
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Recombinant Human FSTL3, His-tagged - FSTL3-1089H from Creative Biomart
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Recombinant Follistatin Like Protein 3 (FSTL3) - RPJ084Mu01 from Uscn Life Science Inc.
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Recombinant Follistatin Like Protein 3 (FSTL3) - RPJ084Mu02 from Uscn Life Science Inc.
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Recombinant Human Follistatin-related protein 3(FSTL3) - CSB-YP009026HU CSB-EP009026HU CSB-BP009026HU CSB-MP009026HU from Cusabio
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Recombinant Human FLRG Protein - 1288-F3 from R&D Systems
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Recombinant Human FLRG Protein, CF - 1288-F3/CF from R&D Systems
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Follistatin-related protein 3 - TP300811 from Acris Antibodies
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Follistatin-related Gene Protein/FLRG/Fstl3 Recombinant Protein Antigen - NBP2-32034PEP from Novus Biologicals
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FSTL3 Peptide, Human - M34GP05933H from Creative Peptides
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Follistatin Like Protein 3, Recombinant Protein - MBS2030084 from MyBioSource
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Follistatin-related protein 3 (FSTL3), Recombinant Protein - MBS1121425 from MyBioSource
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Recombinant Human FLRG Protein - 1288-F3 from Novus Biologicals
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FSTL3 fusion protein - Ag27626 from Proteintech Group
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