FSTL3

Gene Symbol FSTL3
Entrez Gene 10272
Alt Symbol FLRG, FSRP
Species Human
Gene Type protein-coding
Description follistatin-like 3 (secreted glycoprotein)
Other Description follistatin-like protein 3|follistatin-related gene protein|follistatin-related protein 3
Swissprots A8K7E3 O95633
Accessions EAW61165 EAW61166 O95633 AK291958 BAF84647 AK311521 AK311566 AK313341 AL050194 AY358917 AAQ89276 BC005839 AAH05839 BC033119 BQ319646 BX439786 U76702 AAC64321 NM_005860 NP_005851
Function Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. {ECO:0000269|PubMed:11948405, ECO:0000269|PubMed:15451575, ECO:0000269|PubMed:15574124, ECO:0000269|PubMed:16336961, ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:17878677}.
Subcellular Location Isoform 1: Secreted.
Tissue Specificity Expressed in a wide range of tissues. {ECO:0000269|PubMed:11459787}.

Human FSTL3 cDNA clone(NM_005860.2) - CDFH007151 from Creative Biomart

Species Human
Accession NM_005860.2

Human FSTL3 ORF Clone(NM_005860.2) - CDCL164040 from Creative Biomart

Species Human
Accession NM_005860.2

Mouse FSTL3 ORF clone - CDCL109643 from Creative Biomart

Species Human
Accession NM_005860

Mouse FSTL3 ORF clone - CDCL109644 from Creative Biomart

Species Human
Accession NM_005860

Human FSTL3 ORF Clone(NM_005860.2) - CDCR291305 from Creative Biomart

Species Human
Accession NM_005860.2

Human FSTL3 ORF Clone(NM_005860.2) - CDCR291306 from Creative Biomart

Species Human
Accession NM_005860.2

Human FSTL3 ORF Clone(NM_005860.2) - CDCR291307 from Creative Biomart

Species Human
Accession NM_005860.2

Human FSTL3 ORF Clone(NM_005860.2) - CDCR291305 from Creative biogene

Species Human

Human FSTL3 cDNA Clone(NM_005860.2) - CDFH007151 from Creative biogene

Species Human
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