FSTL3

Gene Symbol	FSTL3
Entrez Gene	10272
Alt Symbol	FLRG, FSRP
Species	Human
Gene Type	protein-coding
Description	follistatin-like 3 (secreted glycoprotein)
Other Description	follistatin-like protein 3\|follistatin-related gene protein\|follistatin-related protein 3
Swissprots	A8K7E3 O95633
Accessions	EAW61165 EAW61166 O95633 AK291958 BAF84647 AK311521 AK311566 AK313341 AL050194 AY358917 AAQ89276 BC005839 AAH05839 BC033119 BQ319646 BX439786 U76702 AAC64321 NM_005860 NP_005851
Function	Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. {ECO:0000269\|PubMed:11948405, ECO:0000269\|PubMed:15451575, ECO:0000269\|PubMed:15574124, ECO:0000269\|PubMed:16336961, ECO:0000269\|PubMed:17868029, ECO:0000269\|PubMed:17878677}.
Subcellular Location	Isoform 1: Secreted.
Tissue Specificity	Expressed in a wide range of tissues. {ECO:0000269\|PubMed:11459787}.

Category	Cell Line
Species	Human

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