Gene Symbol | SRRM1 |
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Entrez Gene | 10250 |
Alt Symbol | 160-KD, POP101, SRM160 |
Species | Human |
Gene Type | protein-coding |
Description | serine/arginine repetitive matrix 1 |
Other Description | SR-related nuclear matrix protein of 160 kDa|Ser/Arg-related nuclear matrix protein|serine/arginine repetitive matrix protein 1 |
Swissprots | Q5VVN4 O60585 Q8IYB3 |
Accessions | EAW95138 EAW95139 EAW95140 Q8IYB3 AA744578 AF048977 AAC09321 AF419855 AAP97290 AK293576 BAG57046 AK302498 BAH13726 AK307419 AK307568 AW958761 BC011019 BC017315 BC036187 AAH36187 BC107072 BG178896 BG720378 CX782666 DC353932 XM_005245717 XP_005245774 XM_005245718 XP_005245775 XM_005245720 XP_005245777 XM_005245721 XP_005245778 XM_005245722 XP_005245779 XM_011540478 XP_011538780 XM_011540479 XP_011538781 XM_011540480 XP_011538782 XM_011540481 XP_011538783 XM_011540482 XP_011538784 XM_011540483 XP_011538785 XR_241183 NM_001303448 NP_001290377 NM_001303449 NP_001290378 NM_005839 NP_005830 |
Function | Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537}. |
Subcellular Location | Nucleus matrix. Nucleus speckle. |
Top Pathways | RNA transport, mRNA surveillance pathway |
Serine/arginine repetitive matrix protein 1 (SRRM1), Human, ELISA Kit - E01S0403 from ARP American Research Products
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Serine/arginine repetitive matrix protein 1 (SRRM1), ELISA Kit - MBS7244049 from MyBioSource
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Serine/arginine repetitive matrix protein 1 (SRRM1), ELISA Kit - MBS7227222 from MyBioSource
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Serine/arginine repetitive matrix protein 1 (SRRM1), ELISA Kit - MBS7249770 from MyBioSource
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Serine/arginine repetitive matrix protein 1 (SRRM1), ELISA Kit - MBS7245938 from MyBioSource
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Serine/arginine repetitive matrix protein 1 (SRRM1), ELISA Kit - MBS7238771 from MyBioSource
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Serine/arginine repetitive matrix protein 1 (SRRM1), ELISA Kit - MBS7250102 from MyBioSource
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Serine/arginine repetitive matrix protein 1 (SRRM1), ELISA Kit - MBS7247827 from MyBioSource
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Serine/arginine repetitive matrix protein 1 (SRRM1), ELISA Kit - MBS7233238 from MyBioSource
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Serine/arginine repetitive matrix protein 1 (SRRM1), ELISA Kit - MBS7226078 from MyBioSource
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Serine/arginine repetitive matrix protein 1 (SRRM1), ELISA Kit - MBS7215592 from MyBioSource
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Serine/arginine repetitive matrix protein 1 (SRRM1), ELISA Kit - MBS7223791 from MyBioSource
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Human SRRM1 ELISA Kit - E034753 from Biobool
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