SRRM1

Gene Symbol	SRRM1
Entrez Gene	10250
Alt Symbol	160-KD, POP101, SRM160
Species	Human
Gene Type	protein-coding
Description	serine/arginine repetitive matrix 1
Other Description	SR-related nuclear matrix protein of 160 kDa|Ser/Arg-related nuclear matrix protein|serine/arginine repetitive matrix protein 1
Swissprots	Q5VVN4 O60585 Q8IYB3
Accessions	EAW95138 EAW95139 EAW95140 Q8IYB3 AA744578 AF048977 AAC09321 AF419855 AAP97290 AK293576 BAG57046 AK302498 BAH13726 AK307419 AK307568 AW958761 BC011019 BC017315 BC036187 AAH36187 BC107072 BG178896 BG720378 CX782666 DC353932 XM_005245717 XP_005245774 XM_005245718 XP_005245775 XM_005245720 XP_005245777 XM_005245721 XP_005245778 XM_005245722 XP_005245779 XM_011540478 XP_011538780 XM_011540479 XP_011538781 XM_011540480 XP_011538782 XM_011540481 XP_011538783 XM_011540482 XP_011538784 XM_011540483 XP_011538785 XR_241183 NM_001303448 NP_001290377 NM_001303449 NP_001290378 NM_005839 NP_005830
Function	Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537}.
Subcellular Location	Nucleus matrix. Nucleus speckle.
Top Pathways	RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SRRM1 protein fragment - ab160903 from Abcam Category Protein Source Wheat germ Species Human

SRRM1 Antibody Blocking Peptide - LS-E14848 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SRRM1 Protein - H00010250-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SRRM1 / SRM160 - H00010250-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SRRM1 / SRM160 - H00010250-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SRRM1 fusion protein - ag3513 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Serine/arginine repetitive matrix protein 1(SRRM1) ,partial - CSB-YP815580HU CSB-EP815580HU CSB-BP815580HU CSB-MP815580HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SRm160, Peptide - MBS658208 from MyBioSource Category Peptide Prices $290.00 Sizes 1 mg Species Human, Rodent

SRm160, Peptide - MBS659167 from MyBioSource Category Peptide Prices $290.00 Sizes 1 mg Species Human, Rodent

SRRM1 Protein - NBP2-13381PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

SRRM1 Peptide, Human - M34GP15170H from Creative Peptides Category Peptide Source Synthetic. Species Human

SRRM1 Recombinant Protein Antigen - NBP2-57064PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Serine/arginine repetitive matrix protein 1 (SRRM1), partial, Recombinant Protein - MBS1372976 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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