| Gene Symbol |
SRRM1
|
| Entrez Gene |
10250
|
| Alt Symbol |
160-KD, POP101, SRM160
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serine/arginine repetitive matrix 1
|
| Other Description |
SR-related nuclear matrix protein of 160 kDa|Ser/Arg-related nuclear matrix protein|serine/arginine repetitive matrix protein 1
|
| Swissprots |
Q5VVN4 O60585 Q8IYB3
|
| Accessions |
EAW95138 EAW95139 EAW95140 Q8IYB3 AA744578 AF048977 AAC09321 AF419855 AAP97290 AK293576 BAG57046 AK302498 BAH13726 AK307419 AK307568 AW958761 BC011019 BC017315 BC036187 AAH36187 BC107072 BG178896 BG720378 CX782666 DC353932 XM_005245717 XP_005245774 XM_005245718 XP_005245775 XM_005245720 XP_005245777 XM_005245721 XP_005245778 XM_005245722 XP_005245779 XM_011540478 XP_011538780 XM_011540479 XP_011538781 XM_011540480 XP_011538782 XM_011540481 XP_011538783 XM_011540482 XP_011538784 XM_011540483 XP_011538785 XR_241183 NM_001303448 NP_001290377 NM_001303449 NP_001290378 NM_005839 NP_005830
|
| Function |
Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537}.
|
| Subcellular Location |
Nucleus matrix. Nucleus speckle.
|
| Top Pathways |
RNA transport, mRNA surveillance pathway
|
![Western Blot: SRRM1 Overexpression Lysate (Adult Normal) [NBP2-07693] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SRRM1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/15471_SRRM1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-07693-img0001.jpg)