SRRM1

Gene Symbol SRRM1
Entrez Gene 10250
Alt Symbol 160-KD, POP101, SRM160
Species Human
Gene Type protein-coding
Description serine/arginine repetitive matrix 1
Other Description SR-related nuclear matrix protein of 160 kDa|Ser/Arg-related nuclear matrix protein|serine/arginine repetitive matrix protein 1
Swissprots Q5VVN4 O60585 Q8IYB3
Accessions EAW95138 EAW95139 EAW95140 Q8IYB3 AA744578 AF048977 AAC09321 AF419855 AAP97290 AK293576 BAG57046 AK302498 BAH13726 AK307419 AK307568 AW958761 BC011019 BC017315 BC036187 AAH36187 BC107072 BG178896 BG720378 CX782666 DC353932 XM_005245717 XP_005245774 XM_005245718 XP_005245775 XM_005245720 XP_005245777 XM_005245721 XP_005245778 XM_005245722 XP_005245779 XM_011540478 XP_011538780 XM_011540479 XP_011538781 XM_011540480 XP_011538782 XM_011540481 XP_011538783 XM_011540482 XP_011538784 XM_011540483 XP_011538785 XR_241183 NM_001303448 NP_001290377 NM_001303449 NP_001290378 NM_005839 NP_005830
Function Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537}.
Subcellular Location Nucleus matrix. Nucleus speckle.
Top Pathways RNA transport, mRNA surveillance pathway

SRm160 CRISPR/Cas9 KO Plasmid (h) - sc-405613 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRm160 HDR Plasmid (h) - sc-405613-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRm160 Double Nickase Plasmid (h) - sc-405613-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRm160 Double Nickase Plasmid (h2) - sc-405613-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRm160 CRISPR Activation Plasmid (h) - sc-405613-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRm160 CRISPR Activation Plasmid (h2) - sc-405613-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRm160 Lentiviral Activation Particles (h) - sc-405613-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRm160 Lentiviral Activation Particles (h2) - sc-405613-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRm160 siRNA (h) - sc-38335 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SRm160 shRNA Plasmid (h) - sc-38335-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SRm160 shRNA (h) Lentiviral Particles - sc-38335-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU148531 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20591 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20591 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07545 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07545

SRRM1 siRNA (Human) - CRH6937 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SRRM1 - MBS8213426 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SRRM1(NM_005839.3) - SHL035508 from Creative biogene

Category siRNA
Species Reactivities Human

Human SRRM1 siRNA - orb267439 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SRRM1 shRNA Plasmid (Human) - CHH6937 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SRRM1 miRNA 3'UTR clone - MiUTR1H-09915 from Creative biogene

Species Reactivities Human
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