| Gene Symbol |
MUC16
|
| Entrez Gene |
94025
|
| Alt Symbol |
CA125
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mucin 16, cell surface associated
|
| Other Description |
CA125 ovarian cancer antigen|mucin-16|ovarian cancer-related tumor marker CA125|ovarian carcinoma antigen CA125
|
| Swissprots |
Q6ZQW5 Q96RK2 Q8WXI7
|
| Accessions |
Q8WXI7 AF361486 AAK74120 AF414442 AAL65133 AK024365 BAB14899 AK056791 AK128681 BAC87568 AK128856 BAG54742 AK128857 BAG54743 AM903345 CAP17281 BF359193 BI256451 NM_024690 NP_078966
|
| Function |
Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.
|
| Tissue Specificity |
Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas. {ECO:0000269|PubMed:11369781, ECO:0000269|PubMed:12218296, ECO:0000269|PubMed:16384952}.
|