Gene Symbol | MUC16 |
---|---|
Entrez Gene | 94025 |
Alt Symbol | CA125 |
Species | Human |
Gene Type | protein-coding |
Description | mucin 16, cell surface associated |
Other Description | CA125 ovarian cancer antigen|mucin-16|ovarian cancer-related tumor marker CA125|ovarian carcinoma antigen CA125 |
Swissprots | Q6ZQW5 Q96RK2 Q8WXI7 |
Accessions | Q8WXI7 AF361486 AAK74120 AF414442 AAL65133 AK024365 BAB14899 AK056791 AK128681 BAC87568 AK128856 BAG54742 AK128857 BAG54743 AM903345 CAP17281 BF359193 BI256451 NM_024690 NP_078966 |
Function | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain. |
Tissue Specificity | Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas. {ECO:0000269|PubMed:11369781, ECO:0000269|PubMed:12218296, ECO:0000269|PubMed:16384952}. |
Mucin 16 CRISPR/Cas9 KO Plasmid (h) - sc-403050 from Santa Cruz Biotechnology
|
||||||||
Mucin 16 HDR Plasmid (h) - sc-403050-HDR from Santa Cruz Biotechnology
|
||||||||
Mucin 16 Double Nickase Plasmid (h) - sc-403050-NIC from Santa Cruz Biotechnology
|
||||||||
Mucin 16 Double Nickase Plasmid (h2) - sc-403050-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Mucin 16 CRISPR Activation Plasmid (h) - sc-403050-ACT from Santa Cruz Biotechnology
|
||||||||
Mucin 16 CRISPR Activation Plasmid (h2) - sc-403050-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Mucin 16 Lentiviral Activation Particles (h) - sc-403050-LAC from Santa Cruz Biotechnology
|
||||||||
Mucin 16 Lentiviral Activation Particles (h2) - sc-403050-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Mucin 16 siRNa (h) - sc-44971 from Santa Cruz Biotechnology
|
||||||||
Mucin 16 shRNA Plasmid (h) - sc-44971-SH from Santa Cruz Biotechnology
|
||||||||
Mucin 16 shRNA (h) Lentiviral Particles - sc-44971-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU129291 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN14754 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14754 from Sigma-Aldrich
|
||||||||
MUC16 siRNA (Human) - CRJ4236 from Cohesion Biosciences
|
||||||||
shRNA set against Human MUC16 (NM_024690.2) - SHH346864 from Creative biogene
|
||||||||
Human MUC16 siRNA - orb274737 from Biorbyt
|
||||||||
MUC16 shRNA Plasmid (Human) - CHJ4236 from Cohesion Biosciences
|
||||||||
MUC16 miRNA 3'UTR clone - MiUTR1H-06528 from Creative biogene
|