MUC16

Gene Symbol MUC16
Entrez Gene 94025
Alt Symbol CA125
Species Human
Gene Type protein-coding
Description mucin 16, cell surface associated
Other Description CA125 ovarian cancer antigen|mucin-16|ovarian cancer-related tumor marker CA125|ovarian carcinoma antigen CA125
Swissprots Q6ZQW5 Q96RK2 Q8WXI7
Accessions Q8WXI7 AF361486 AAK74120 AF414442 AAL65133 AK024365 BAB14899 AK056791 AK128681 BAC87568 AK128856 BAG54742 AK128857 BAG54743 AM903345 CAP17281 BF359193 BI256451 NM_024690 NP_078966
Function Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}.
Subcellular Location Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.
Tissue Specificity Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas. {ECO:0000269|PubMed:11369781, ECO:0000269|PubMed:12218296, ECO:0000269|PubMed:16384952}.

Mucin 16 (C-6) - sc-365002 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mucin 16 (C-6): sc-365002. Western blot analysis of Mucin 16 expression in MDA-MB-468 whole cell lysate.

Mucin 16 (C-20) - sc-33346 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Mucin 16 (N-20) - sc-33344 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Mucin 16 (X306) - sc-52095 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Mucin 16 (X306): sc-52095. Western blot analysis of Mucin 16 expression in HeLa whole cell lysate.

Mucin 16 (X325) - sc-52096 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Anti-CA 125 antibody [EPR1020(2)] - ab110640 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1020(2)
Anti-CA 125 antibody [EPR1020(2)] (ab110640) at 1/1000 dilution + Human uterus cell lysate at 10 µg

Anti-MUC16 antibody - ab133419 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human uterus, endometrium tissue labelling MUC16 with ab133419 antibody at 5µg/ml, followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-MUC16 antibody - ab89365 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Left panel: ab89365 at 1/100 dilution staining MUC16 in formalin-fixed, paraffin-embedded Human colon carcinoma tissue by immunohistochemistry . Right panel: same, after pre-treatment with the immunizing peptide.

Anti-MUC16 antibody - ab99475 from Abcam

Prices $368.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-MUC16 antibody [2F1] - ab63903 from Abcam

Prices $370.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone 2F1

Anti-MUC16 antibody [618F] - ab81871 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 618F

Anti-MUC16 antibody [EPSISR23] - ab134093 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPSISR23
Overlay histogram showing Hela cells stained with ab134093 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab134093, 1/100 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HeLa cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-MUC16 antibody [EPSISR23] - ab168360 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPSISR23
All lanes : Anti-MUC16 antibody [EPSISR23] (ab168360) at 1/1000 dilutionLane 1 : NIH:OVCAR-3 lysateLane 2 : Human ovary cancer lysateLane 3 : Human uterus lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-MUC16 antibody [M002201] - ab117614 from Abcam

Host Mouse
Clonality Monoclonal
Clone M002201
ab117614, at 5 µg/ml, staining MUC16 in Formalin-fixed, Paraffin-embedded Human Uterus, Endometrium tissue by Immunohistochemistry.

Anti-MUC16 antibody [OC125] - ab693 from Abcam

Prices $382.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone OC125
Overlay histogram showing HeLa cells stained with ab693 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab693, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed. This antibody gave a positive signal in HeLa cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-MUC16 antibody [OV185:1] - ab697 from Abcam

Prices $376.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone OV185:1
Overlay histogram showing HeLa cells stained with ab697 (red line). The cells were fixed with 80% methanol (5 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab697, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 2µg/1x106 cells) used under the same conditions. Unlabelled sample (blue line). Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.

Anti-MUC16 antibody [SPM111] - ab15142 from Abcam

Prices $376.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone SPM111
ab15142 staining CA125 in human colon carcinoma by Immunohistochemistry (Formalin/ PFA fixed paraffin embedded tissue sections).

Anti-MUC16 antibody [SPM111], prediluted - ab15144 from Abcam

Host Mouse
Clonality Monoclonal
Clone SPM111
ab15144 staining MUC16 in human colon carcinoma by Immunohistochemistry (Formalin/ PFA fixed paraffin embedded tissue sections).

Anti-MUC16 antibody [X306] (Biotin) - ab90346 from Abcam

Prices $370.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone X306

Anti-MUC16 antibody [X325] - ab10033 from Abcam

Prices $390.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone X325
ab10033 staining MUC16 in Human lung tissue (alveolocytes type II) by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Anti-MUC16 antibody [X75] - ab1107 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone X75
Overlay histogram showing HeLa cells stained with ab1107 (red line). The cells were fixed with 80% methanol (5 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab1107, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive result in 4% paraformaldehyde (10 min) fixed HeLa cells used under the same conditions. Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.

Anti-MUC16 antibody [X75] - ab10029 from Abcam

Prices $378.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone X75
Overlay histogram showing HeLa cells stained with ab10029 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab462, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HeLa cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-CA125 Antibody - LS-C92220 from LifeSpan Bioscience

Prices $455.00
Sizes 1 mg
Host Mouse
Clonality Monoclonal

Anti-CA125 Antibody - LS-C194348 from LifeSpan Bioscience

Prices $395.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal

Anti-CA125 Antibody (clone OC125) - LS-C311949 from LifeSpan Bioscience

Prices $225.00, $435.00, $695.00
Sizes 100 µl, 500 µl, 1 ml
Host Mouse
Clonality Monoclonal
Clone OC125
IHC of CA-125 on FFPE Ovarian Carcinoma tissue.
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