PPP4R2

Gene Symbol PPP4R2
Entrez Gene 151987
Alt Symbol PP4R2
Species Human
Gene Type protein-coding
Description protein phosphatase 4, regulatory subunit 2
Other Description serine/threonine-protein phosphatase 4 regulatory subunit 2
Swissprots A8K1I6 Q8WXX6 Q498B8 Q9NY27 Q2TAJ9
Accessions EAW65530 Q9NY27 AF327345 AAL56006 AJ271448 CAB93534 AK289901 BAF82590 AL833216 BC100281 AAI00282 BC110889 AAI10890 BC128136 AAI28137 BC128137 AAI28138 NM_174907 NP_777567
Function Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {ECO:0000269|PubMed:10769191, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:20154705}.
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:12668731}.

PP4R2 (P-17) - sc-100101 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
PP4R2 (P-17): sc-100101. Western blot analysis of PP4R2 expression in HeLa whole cell lysate.

Anti-PPP4R2 antibody - ab70631 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PPP4R2 antibody (ab70631) at 0.04 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µgLane 5 : NIH3T3 whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-PPP4R2 antibody - ab174174 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PPP4R2 antibody (ab174174) at 1/100 dilution + Mouse brain tissue lysates at 35 µg

Anti-PPP4R2 antibody - ab82693 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PPP4R2 antibody (ab82693) at 1 µg/ml + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-PPP4R2 antibody - ab137928 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PPP4R2 antibody (ab137928) at 1/500 dilution + COLO205 cell lysate at 30 µg

Anti-PPP4R2 Antibody (C-Terminus) - LS-C91594 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-PPP4R2 Antibody (aa228-254, APC) - LS-C239368 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP4R2 Antibody (aa228-254, AP) - LS-C239369 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP4R2 Antibody (aa228-254, Biotin) - LS-C239370 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP4R2 Antibody (aa228-254, FITC) - LS-C239371 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP4R2 Antibody (aa228-254, PE) - LS-C239373 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP4R2 Antibody (aa163-212) - LS-C200521 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from COLO205 cells using PPP4R2 antibody.

Anti-PPP4R2 Antibody (aa228-254, Azide-free, HRP) - LS-C248538 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP4R2 Antibody (aa227-254) - LS-C324251 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP4R2 Antibody (aa171-220) - LS-C120380 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from K562/COS7 cells, using PPP4R2 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-PPP4R2 Antibody (aa288-337) - LS-C80524 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-PPP4R2 Antibody (aa228-254) - LS-C158718 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PPP4R2 Antibody western blot of mouse brain tissue lysates (35 ug/lane). The PPP4R2 antibody detected the PPP4R2 protein (arrow).

Anti-PPP4R2 Antibody - LS-C155687 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: Non-transfected 293T lysates B: PPP4R2 transfected 293T lysate 10% SDS PAGE PPP4R2 antibody diluted at 1:5000

Anti-PPP4R2 Antibody (C-Terminus) - LS-C287686 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human PPP4R2 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) prepared using NETN buffer from HeLa cells. Antibodies: Affinity purified rabbit anti-PPP4R2 antibody used for IP at 6 ug per reaction. PPP4R2 was also immunoprecipitated by a previous lot of this antibody. For blotting immunoprecipitated PPP4R2 , was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

PPP4R2 Antibody - NB100-2877 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: PPP4R2 Antibody [NB100-2877] - Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti- PPP4R2 used at a dilution of 1:200 (1ug/ml). Detection: DAB

PPP4R2 Antibody - NBP2-38453 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PPP4R2 Antibody - NBP1-89432 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: PPP4R2 Antibody [NBP1-89432] - Staining of human pancreas shows strong nuclear positivity in exocrine glandular cells.

PPP4R2 Antibody - NBP2-19915 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PPP4R2 Antibody [NBP2-19915] - Sample (30 ug of whole cell lysate) A: Non-transfected 293T lysates B: PPP4R2 transfected 293T lysate 10% SDS PAGE gel, diluted at 1:5000.

PPP4R2 Antibody - NBP2-19914 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PPP4R2 Antibody [NBP2-19914] - Sample (30 ug of whole cell lysate) A: Non-transfected 293T lysates B: PPP4R2 transfected 293T lysate 10% SDS PAGE gel, diluted at 1:5000.

PPP4R2 Antibody - NBP2-19916 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
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