PPP4R2

Gene Symbol	PPP4R2
Entrez Gene	151987
Alt Symbol	PP4R2
Species	Human
Gene Type	protein-coding
Description	protein phosphatase 4, regulatory subunit 2
Other Description	serine/threonine-protein phosphatase 4 regulatory subunit 2
Swissprots	A8K1I6 Q8WXX6 Q498B8 Q9NY27 Q2TAJ9
Accessions	EAW65530 Q9NY27 AF327345 AAL56006 AJ271448 CAB93534 AK289901 BAF82590 AL833216 BC100281 AAI00282 BC110889 AAI10890 BC128136 AAI28137 BC128137 AAI28138 NM_174907 NP_777567
Function	Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {ECO:0000269|PubMed:10769191, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:20154705}.
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:12668731}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PPP4R2 Antibody Blocking Peptide - LS-E5918 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP4R2 Antibody Blocking Peptide - LS-E15732 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP4R2-Antibody-Center-Blocking-Peptide - BP18485c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PPP4R2 Blocking Peptide - 33R-2177 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PPP4R2 fusion protein - ag18486 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PPP4R2 fusion protein - Ag18165 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human Serine/threonine-protein phosphatase 4 regulatory subunit 2(PP - CSB-YP889144HU CSB-EP889144HU CSB-BP889144HU CSB-MP889144HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PPP4R2 Protein - abx164897 from Abbexa Category Protein Species Human

PPP4R2 Recombinant Protein Antigen - NBP2-38453PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PPP4R2 Recombinant Protein Antigen - NBP1-89432PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PPP4R2 Blocking Peptide - abx061319 from Abbexa Category Peptide Species Human, Monkey

PPP4R2 Peptide, Human - M34GP12292H from Creative Peptides Category Peptide Source Synthetic. Species Human

PPP4R2 Blocking Peptide - CBP5232 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Monkey

PPP4R2 Recombinant Protein Antigen - NBP2-58011PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2), Recombinant Protein - MBS1455983 from MyBioSource Category Protein Prices $1,190.00, $1,190.00, $1,410.00, $1,410.00, $1,920.00, $1,920.00, $2,385.00, $2,385.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PPP4R2 peptide - orb319378 from Biorbyt Category Peptide

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