| Gene Symbol |
PPP4R2
|
| Entrez Gene |
151987
|
| Alt Symbol |
PP4R2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 4, regulatory subunit 2
|
| Other Description |
serine/threonine-protein phosphatase 4 regulatory subunit 2
|
| Swissprots |
A8K1I6 Q8WXX6 Q498B8 Q9NY27 Q2TAJ9
|
| Accessions |
EAW65530 Q9NY27 AF327345 AAL56006 AJ271448 CAB93534 AK289901 BAF82590 AL833216 BC100281 AAI00282 BC110889 AAI10890 BC128136 AAI28137 BC128137 AAI28138 NM_174907 NP_777567
|
| Function |
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {ECO:0000269|PubMed:10769191, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:20154705}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:12668731}.
|