| Gene Symbol | PPP4R2 |
|---|---|
| Entrez Gene | 151987 |
| Alt Symbol | PP4R2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein phosphatase 4, regulatory subunit 2 |
| Other Description | serine/threonine-protein phosphatase 4 regulatory subunit 2 |
| Swissprots | A8K1I6 Q8WXX6 Q498B8 Q9NY27 Q2TAJ9 |
| Accessions | EAW65530 Q9NY27 AF327345 AAL56006 AJ271448 CAB93534 AK289901 BAF82590 AL833216 BC100281 AAI00282 BC110889 AAI10890 BC128136 AAI28137 BC128137 AAI28138 NM_174907 NP_777567 |
| Function | Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {ECO:0000269|PubMed:10769191, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:20154705}. |
| Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:12668731}. |