| Gene Symbol | RALB |
|---|---|
| Entrez Gene | 5899 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | v-ral simian leukemia viral oncogene homolog B |
| Other Description | RAS-like protein B|ras related GTP binding protein B|ras-related protein Ral-B|v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) |
| Swissprots | B4E040 P11234 Q6ZS74 Q53T32 |
| Accessions | AAY14800 EAW95240 EAW95241 EAW95242 P11234 AF493911 AAM12625 AK127675 BAC87080 AK303214 BAG64302 AK304588 BAG65376 AK312453 BAG35360 BC018163 AAH18163 BQ893549 BT006953 AAP35599 JF432766 ADZ15983 M35416 AAA60250 X15015 CAA33119 XM_005263724 XP_005263781 XM_005263727 XP_005263784 XM_005263728 XP_005263785 XM_005263729 XP_005263786 XM_011511573 XP_011509875 XM_011511574 XP_011509876 NM_002881 NP_002872 |
| Function | Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis. {ECO:0000269|PubMed:18756269}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:17875936, ECO:0000269|PubMed:18756269}; Lipid-anchor {ECO:0000269|PubMed:17875936, ECO:0000269|PubMed:18756269}; Cytoplasmic side {ECO:0000269|PubMed:17875936, ECO:0000269|PubMed:18756269}. Note=During late cytokinesis localizes at the midbody. |
| Top Pathways | Pancreatic cancer, Rap1 signaling pathway |