RALB
| Gene Symbol | RALB |
|---|---|
| Entrez Gene | 5899 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | v-ral simian leukemia viral oncogene homolog B |
| Other Description | RAS-like protein B|ras related GTP binding protein B|ras-related protein Ral-B|v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) |
| Swissprots | B4E040 P11234 Q6ZS74 Q53T32 |
| Accessions | AAY14800 EAW95240 EAW95241 EAW95242 P11234 AF493911 AAM12625 AK127675 BAC87080 AK303214 BAG64302 AK304588 BAG65376 AK312453 BAG35360 BC018163 AAH18163 BQ893549 BT006953 AAP35599 JF432766 ADZ15983 M35416 AAA60250 X15015 CAA33119 XM_005263724 XP_005263781 XM_005263727 XP_005263784 XM_005263728 XP_005263785 XM_005263729 XP_005263786 XM_011511573 XP_011509875 XM_011511574 XP_011509876 NM_002881 NP_002872 |
| Function | Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis. {ECO:0000269|PubMed:18756269}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:17875936, ECO:0000269|PubMed:18756269}; Lipid-anchor {ECO:0000269|PubMed:17875936, ECO:0000269|PubMed:18756269}; Cytoplasmic side {ECO:0000269|PubMed:17875936, ECO:0000269|PubMed:18756269}. Note=During late cytokinesis localizes at the midbody. |
| Top Pathways | Pancreatic cancer, Rap1 signaling pathway |
Ral B CRISPR/Cas9 KO Plasmid (h) - sc-403971 from Santa Cruz Biotechnology
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Ral B HDR Plasmid (h) - sc-403971-HDR from Santa Cruz Biotechnology
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Ral B Double Nickase Plasmid (h) - sc-403971-NIC from Santa Cruz Biotechnology
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Ral B Double Nickase Plasmid (h2) - sc-403971-NIC-2 from Santa Cruz Biotechnology
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Ral B CRISPR Activation Plasmid (h) - sc-403971-ACT from Santa Cruz Biotechnology
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Ral B CRISPR Activation Plasmid (h2) - sc-403971-ACT-2 from Santa Cruz Biotechnology
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Ral B Lentiviral Activation Particles (h) - sc-403971-LAC from Santa Cruz Biotechnology
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Ral B Lentiviral Activation Particles (h2) - sc-403971-LAC-2 from Santa Cruz Biotechnology
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Ral B siRNA (h) - sc-41844 from Santa Cruz Biotechnology
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Ral B shRNA Plasmid (h) - sc-41844-SH from Santa Cruz Biotechnology
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Ral B shRNA (h) Lentiviral Particles - sc-41844-V from Santa Cruz Biotechnology
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Ral B siRNA (h2) - sc-156068 from Santa Cruz Biotechnology
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Ral B shRNA Plasmid (h2) - sc-156068-SH from Santa Cruz Biotechnology
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Ral B shRNA (h2) Lentiviral Particles - sc-156068-V from Santa Cruz Biotechnology
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RalB RNAi - H00005899-R01 from Novus Biologicals
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MISSION® esiRNA - EHU044271 from Sigma-Aldrich
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MISSION® siRNA - SIHK1929 from Sigma-Aldrich
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MISSION® siRNA - SIHK1927 from Sigma-Aldrich
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MISSION® siRNA - SIHK1928 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17922 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17922 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09286 from Sigma-Aldrich
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RALB siRNA (Human) - CRH3987 from Cohesion Biosciences
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RALB - MBS8232000 from MyBioSource
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shRNA set against Human RALB (NM_002881.2) - SHH389300 from Creative biogene
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