Gene Symbol | SPIC |
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Entrez Gene | 121599 |
Alt Symbol | SPI-C |
Species | Human |
Gene Type | protein-coding |
Description | Spi-C transcription factor (Spi-1/PU.1 related) |
Other Description | transcription factor Spi-C |
Swissprots | Q8N5J4 |
Accessions | CCQ77680 EAW97662 Q8N5J4 AF518404 AAN84476 BC032317 AAH32317 EU446849 ABZ92378 XM_005268646 XP_005268703 XM_006719239 XP_006719302 NM_152323 NP_689536 |
Function | Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone marrow and fetal liver. {ECO:0000269|PubMed:12459275}. |
Spi-C (H-130) - sc-135286 from Santa Cruz Biotechnology
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Spi-C (N-20) - sc-79604 from Santa Cruz Biotechnology
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Spi-C (G-20) - sc-79600 from Santa Cruz Biotechnology
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Spi-C (K-20) - sc-79601 from Santa Cruz Biotechnology
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Anti-Spic antibody - ab86499 from Abcam
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Anti-Spic antibody - ab138304 from Abcam
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Anti-Spic antibody - ab118953 from Abcam
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Anti-Spic antibody - ab183857 from Abcam
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Anti-SPIC Antibody (N-Terminus) - LS-C30650 from LifeSpan Bioscience
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Anti-SPIC Antibody (aa148-197) - LS-C145753 from LifeSpan Bioscience
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Anti-SPIC Antibody (N-Terminus) - LS-C101804 from LifeSpan Bioscience
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Anti-SPIC Antibody (C-Terminus) - LS-C110452 from LifeSpan Bioscience
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Anti-SPIC Antibody (aa131-180) - LS-C119144 from LifeSpan Bioscience
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Anti-SPIC Antibody (aa92-141) - LS-C200716 from LifeSpan Bioscience
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SPIC Antibody - NBP1-82691 from Novus Biologicals
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Anti-SPIC antibody produced in rabbit - HPA042864 from Sigma-Aldrich
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Anti-SPIC (ab2) antibody produced in rabbit - SAB2102285 from Sigma-Aldrich
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Anti-SPIC antibody produced in rabbit - SAB4500315 from Sigma-Aldrich
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Anti-SPIC (ab1) antibody produced in rabbit - SAB2102284 from Sigma-Aldrich
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SPIC antibody - C-terminal region (ARP32232_P050) - ARP32232_P050 from Aviva Systems Biology
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SPIC antibody - N-terminal region (ARP39881_P050) - ARP39881_P050 from Aviva Systems Biology
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SPIC antibody - middle region (ARP39882_P050) - ARP39882_P050 from Aviva Systems Biology
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SPIC-Antibody - AP50791 from Abgent, a WuXi AppTec company
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SPIC Antibody (OAAB18584) - OAAB18584 from Aviva Systems Biology
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SPIC Antibody (OAAF02544) - OAAF02544 from Aviva Systems Biology
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