Gene Symbol | SPIC |
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Entrez Gene | 121599 |
Alt Symbol | SPI-C |
Species | Human |
Gene Type | protein-coding |
Description | Spi-C transcription factor (Spi-1/PU.1 related) |
Other Description | transcription factor Spi-C |
Swissprots | Q8N5J4 |
Accessions | CCQ77680 EAW97662 Q8N5J4 AF518404 AAN84476 BC032317 AAH32317 EU446849 ABZ92378 XM_005268646 XP_005268703 XM_006719239 XP_006719302 NM_152323 NP_689536 |
Function | Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone marrow and fetal liver. {ECO:0000269|PubMed:12459275}. |
Spi-C CRISPR/Cas9 KO Plasmid (h) - sc-414173 from Santa Cruz Biotechnology
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Spi-C HDR Plasmid (h) - sc-414173-HDR from Santa Cruz Biotechnology
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Spi-C Double Nickase Plasmid (h) - sc-414173-NIC from Santa Cruz Biotechnology
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Spi-C Double Nickase Plasmid (h2) - sc-414173-NIC-2 from Santa Cruz Biotechnology
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Spi-C CRISPR Activation Plasmid (h) - sc-414173-ACT from Santa Cruz Biotechnology
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Spi-C CRISPR Activation Plasmid (h2) - sc-414173-ACT-2 from Santa Cruz Biotechnology
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Spi-C Lentiviral Activation Particles (h) - sc-414173-LAC from Santa Cruz Biotechnology
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Spi-C Lentiviral Activation Particles (h2) - sc-414173-LAC-2 from Santa Cruz Biotechnology
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Spi-C siRNA (h) - sc-76561 from Santa Cruz Biotechnology
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Spi-C shRNA Plasmid (h) - sc-76561-SH from Santa Cruz Biotechnology
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Spi-C shRNA (h) Lentiviral Particles - sc-76561-V from Santa Cruz Biotechnology
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SPIC RNAi - H00121599-R01 from Novus Biologicals
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MISSION® esiRNA - EHU016081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20471 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01432 from Sigma-Aldrich
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SPIC siRNA (Human) - CRJ4681 from Cohesion Biosciences
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SPIC - MBS8240807 from MyBioSource
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shRNA set against Human SPIC (NM_152323.1) - SHH416660 from Creative biogene
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shRNA set against Human SPIC(NM_152323.1) - SHL028668 from Creative biogene
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Human SPIC siRNA - orb275182 from Biorbyt
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SPIC shRNA Plasmid (Human) - CHJ4681 from Cohesion Biosciences
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SPIC miRNA 3'UTR clone - MiUTR1H-09838 from Creative biogene
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