| Gene Symbol |
SPIC
|
| Entrez Gene |
121599
|
| Alt Symbol |
SPI-C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Spi-C transcription factor (Spi-1/PU.1 related)
|
| Other Description |
transcription factor Spi-C
|
| Swissprots |
Q8N5J4
|
| Accessions |
CCQ77680 EAW97662 Q8N5J4 AF518404 AAN84476 BC032317 AAH32317 EU446849 ABZ92378 XM_005268646 XP_005268703 XM_006719239 XP_006719302 NM_152323 NP_689536
|
| Function |
Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone marrow and fetal liver. {ECO:0000269|PubMed:12459275}.
|
