Gene Symbol | SPIC |
---|---|
Entrez Gene | 121599 |
Alt Symbol | SPI-C |
Species | Human |
Gene Type | protein-coding |
Description | Spi-C transcription factor (Spi-1/PU.1 related) |
Other Description | transcription factor Spi-C |
Swissprots | Q8N5J4 |
Accessions | CCQ77680 EAW97662 Q8N5J4 AF518404 AAN84476 BC032317 AAH32317 EU446849 ABZ92378 XM_005268646 XP_005268703 XM_006719239 XP_006719302 NM_152323 NP_689536 |
Function | Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone marrow and fetal liver. {ECO:0000269|PubMed:12459275}. |