| Gene Symbol |
DACH1
|
| Entrez Gene |
1602
|
| Alt Symbol |
DACH
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dachshund family transcription factor 1
|
| Other Description |
dac homolog|dachshund homolog 1
|
| Swissprots |
Q96SG3 Q9H524 D0FY36 D0FY35 Q5VYY4 O75523 Q96SG4 O75687 Q5VYY3 Q9UMH4 Q9UI36
|
| Accessions |
EAW80508 EAW80509 EAW80510 EAW80511 EAW80512 Q9UI36 AA007235 AF069509 AAC33466 AF102546 AAF01351 AF356492 AAL08487 AJ005670 CAA06666 AK001000 AL079278 CAB45153 BC021219 AAH21219 BC166617 AAI66617 BM476209 BQ440916 BQ938052 BQ951567 XM_011534939 XP_011533241 XM_011534940 XP_011533242 XM_011534941 XP_011533243 XM_011534942 XP_011533244 NM_004392 NP_004383 NM_080759 NP_542937 NM_080760 NP_542938
|
| Function |
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin- dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:14525983}.
|
| Tissue Specificity |
Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen. {ECO:0000269|PubMed:11543628}.
|
![Western Blot: DACH1 Overexpression Lysate (Adult Normal) [NBP2-05764] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DACH1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/15005_DACH1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-05764-img0001.jpg)