Gene Symbol | DACH1 |
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Entrez Gene | 1602 |
Alt Symbol | DACH |
Species | Human |
Gene Type | protein-coding |
Description | dachshund family transcription factor 1 |
Other Description | dac homolog|dachshund homolog 1 |
Swissprots | Q96SG3 Q9H524 D0FY36 D0FY35 Q5VYY4 O75523 Q96SG4 O75687 Q5VYY3 Q9UMH4 Q9UI36 |
Accessions | EAW80508 EAW80509 EAW80510 EAW80511 EAW80512 Q9UI36 AA007235 AF069509 AAC33466 AF102546 AAF01351 AF356492 AAL08487 AJ005670 CAA06666 AK001000 AL079278 CAB45153 BC021219 AAH21219 BC166617 AAI66617 BM476209 BQ440916 BQ938052 BQ951567 XM_011534939 XP_011533241 XM_011534940 XP_011533242 XM_011534941 XP_011533243 XM_011534942 XP_011533244 NM_004392 NP_004383 NM_080759 NP_542937 NM_080760 NP_542938 |
Function | Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin- dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:14525983}. |
Tissue Specificity | Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen. {ECO:0000269|PubMed:11543628}. |
DACH1 CRISPR/Cas9 KO Plasmid (h) - sc-404712 from Santa Cruz Biotechnology
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DACH1 HDR Plasmid (h) - sc-404712-HDR from Santa Cruz Biotechnology
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DACH1 Double Nickase Plasmid (h) - sc-404712-NIC from Santa Cruz Biotechnology
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DACH1 Double Nickase Plasmid (h2) - sc-404712-NIC-2 from Santa Cruz Biotechnology
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DACH1 CRISPR Activation Plasmid (h) - sc-404712-ACT from Santa Cruz Biotechnology
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DACH1 CRISPR Activation Plasmid (h2) - sc-404712-ACT-2 from Santa Cruz Biotechnology
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DACH1 Lentiviral Activation Particles (h) - sc-404712-LAC from Santa Cruz Biotechnology
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DACH1 Lentiviral Activation Particles (h2) - sc-404712-LAC-2 from Santa Cruz Biotechnology
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DACH1 siRNA (h) - sc-77089 from Santa Cruz Biotechnology
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DACH1 shRNA Plasmid (h) - sc-77089-SH from Santa Cruz Biotechnology
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DACH1 shRNA (h) Lentiviral Particles - sc-77089-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU123451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6912 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6912 from Sigma-Aldrich
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DACH1 siRNA (Human) - CRH1125 from Cohesion Biosciences
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DACH1 RNAi - H00001602-R03 from Novus Biologicals
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DACH1 RNAi - H00001602-R02 from Novus Biologicals
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DACH1 RNAi - H00001602-R01 from Novus Biologicals
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DACH1 - MBS8209478 from MyBioSource
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Human DACH1 siRNA - orb261627 from Biorbyt
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DACH1 shRNA Plasmid (Human) - CHH1125 from Cohesion Biosciences
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DACH1 miRNA 3'UTR clone - MiUTR4H-TG11041 from Creative biogene
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