| Gene Symbol | DACH1 |
|---|---|
| Entrez Gene | 1602 |
| Alt Symbol | DACH |
| Species | Human |
| Gene Type | protein-coding |
| Description | dachshund family transcription factor 1 |
| Other Description | dac homolog|dachshund homolog 1 |
| Swissprots | Q96SG3 Q9H524 D0FY36 D0FY35 Q5VYY4 O75523 Q96SG4 O75687 Q5VYY3 Q9UMH4 Q9UI36 |
| Accessions | EAW80508 EAW80509 EAW80510 EAW80511 EAW80512 Q9UI36 AA007235 AF069509 AAC33466 AF102546 AAF01351 AF356492 AAL08487 AJ005670 CAA06666 AK001000 AL079278 CAB45153 BC021219 AAH21219 BC166617 AAI66617 BM476209 BQ440916 BQ938052 BQ951567 XM_011534939 XP_011533241 XM_011534940 XP_011533242 XM_011534941 XP_011533243 XM_011534942 XP_011533244 NM_004392 NP_004383 NM_080759 NP_542937 NM_080760 NP_542938 |
| Function | Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin- dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:14525983}. |
| Tissue Specificity | Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen. {ECO:0000269|PubMed:11543628}. |
DACH1 - MBS1270574 from MyBioSource
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Human DACH1 cDNA clone(NM_080759.4) - CDFG007473 from Creative Biomart
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Human DACH1 cDNA clone(NM_080760.4) - CDFG007476 from Creative Biomart
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Human DACH1 cDNA clone(NM_004392.5) - CDFH004720 from Creative Biomart
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Human DACH1 ORF Clone(NM_004392.5) - CDCR287785 from Creative Biomart
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Human DACH1 ORF Clone(NM_004392.5) - CDCR287786 from Creative Biomart
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Human DACH1 ORF Clone(NM_004392.5) - CDCR287787 from Creative Biomart
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Human DACH1 ORF Clone(NM_004392.5) - CDCR287938 from Creative Biomart
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Human DACH1 ORF Clone(NM_080759.4) - CDCR315241 from Creative Biomart
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Human DACH1 ORF Clone(NM_080759.4) - CDCR315243 from Creative Biomart
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Human DACH1 ORF Clone(NM_080760.4) - CDCR315244 from Creative Biomart
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Human DACH1 ORF Clone(NM_080760.4) - CDCR315245 from Creative Biomart
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Human DACH1 ORF Clone(NM_080760.4) - CDCR315246 from Creative Biomart
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Human DACH1 ORF Clone(NM_080760.4) - CDCR315247 from Creative Biomart
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Human DACH1 ORF clone (NM_004392.5) - CDCR053320 from Creative biogene
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Human DACH1 ORF clone (NM_080760.4) - CDCR053322 from Creative biogene
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Human DACH1 ORF clone (NM_080759.4) - CDCR053324 from Creative biogene
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Human DACH1 ORF Clone (BC021219) - CDCS411759 from Creative biogene
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Human DACH1 cDNA Clone(NM_080759.4) - CDFG007473 from Creative biogene
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Human DACH1 cDNA Clone(NM_080760.4) - CDFG007476 from Creative biogene
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Human DACH1 cDNA Clone(NM_004392.5) - CDFH004720 from Creative biogene
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