DACH1

Gene Symbol	DACH1
Entrez Gene	1602
Alt Symbol	DACH
Species	Human
Gene Type	protein-coding
Description	dachshund family transcription factor 1
Other Description	dac homolog\|dachshund homolog 1
Swissprots	Q96SG3 Q9H524 D0FY36 D0FY35 Q5VYY4 O75523 Q96SG4 O75687 Q5VYY3 Q9UMH4 Q9UI36
Accessions	EAW80508 EAW80509 EAW80510 EAW80511 EAW80512 Q9UI36 AA007235 AF069509 AAC33466 AF102546 AAF01351 AF356492 AAL08487 AJ005670 CAA06666 AK001000 AL079278 CAB45153 BC021219 AAH21219 BC166617 AAI66617 BM476209 BQ440916 BQ938052 BQ951567 XM_011534939 XP_011533241 XM_011534940 XP_011533242 XM_011534941 XP_011533243 XM_011534942 XP_011533244 NM_004392 NP_004383 NM_080759 NP_542937 NM_080760 NP_542938
Function	Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin- dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:14525983}.
Tissue Specificity	Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen. {ECO:0000269\|PubMed:11543628}.

DACH1 (A-6) - sc-398706 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

DACH1 (A-6): sc-398706. Western blot analysis of DACH1 expression in HeLa (A), Jurkat (B) and MCF7 (C) whole cell lysates and human kidney (D) and mouse kidney (E) tissue extracts.

DACH1 (H-93) - sc-98563 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

DACH1 (H-93): sc-98563. Immunofluorescence staining of formalin-fixed HeLa cells showing nuclear and cytoplasmic localization. Kindly provided by Yang Xiang, Ph.D., Division of Newborn Medicine, Boston Childrens Hospital, Cell Biology Department, Harvard Medical School.

DACH1 (P-12) - sc-70256 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

DACH1 (S-14) - sc-70258 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Anti-DACH1 antibody - ab173330 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DACH1 antibody (ab173330) at 1/100 dilution + Mouse lung tissue lysate at 35 µg

Anti-DACH1 antibody - ab106838 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-DACH1 antibody (ab106838) at 0.1 µg/ml + Human Kidney lysate in RIPA buffer at 35 µg

Anti-DACH1 antibody - ab94472 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DACH1 antibody (ab94472) at 1 µg/ml (in 5% skim milk / PBS buffer) + HT1080 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-DACH1 antibody [EPR2841Y] - ab77234 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR2841Y

All lanes : Anti-DACH1 antibody [EPR2841Y] (ab77234) at 1/1000 dilutionLane 1 : MCF-7 cell lysateLane 2 : Hela cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-DACH / DACH1 Antibody (aa270-297, Biotin) - LS-C213498 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DACH / DACH1 Antibody (N-Terminus) - LS-C110438 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

DACH1 antibody LS-C110438 Western blot of HT1080 cell lysate.

Anti-DACH / DACH1 Antibody (aa270-297, FITC) - LS-C213499 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DACH / DACH1 Antibody (C-Terminus) - LS-C116908 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

DACH1 antibody LS-C116908 Western blot of Jurkat lysate.

Anti-DACH / DACH1 Antibody (aa270-297, PE) - LS-C213500 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DACH / DACH1 Antibody (aa270-297, Azide-free, HRP) - LS-C213501 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DACH / DACH1 Antibody (C-Terminus, clone EPR1427Y) - LS-C105436 from LifeSpan Bioscience

Prices	$450.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR1427Y

Western blot analysis on (A) MCF-7 and (B) HeLa cell lysate using anti-Dachshund1 antibody (LS-C105436), dilution 1:1000.

Anti-DACH / DACH1 Antibody (aa720-740) - LS-C290221 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DACH / DACH1 Antibody (aa270-297) - LS-C159434 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

DACH1 Antibody western blot of mouse lung tissue lysates (35 ug/lane). The DACH1 antibody detected the DACH1 protein (arrow).

Anti-DACH / DACH1 Antibody (aa740-760) - LS-C290223 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DACH / DACH1 Antibody (aa269-297) - LS-C320731 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DACH / DACH1 Antibody (aa474-491) - LS-C148748 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

IHC of Dach1 in formalin-fixed, paraffin-embedded human kidney tissue using an isotype control (top left) and LS-C148748 (bottom left, right) at 5 ug/ml.

Anti-DACH / DACH1 Antibody (aa270-297, AP) - LS-C213496 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DACH / DACH1 Antibody (aa270-297, APC) - LS-C213497 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

DACH1 Antibody - NBP2-27192 from Novus Biologicals

Prices	$99.00, $229.00
Sizes	25 µg, 100 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: DACH1 Antibody [NBP2-27192] - Analysis of DACH1 in human placenta lysate using NBP2-27192 at 5 ug/ml.

DACH1 Antibody - NBP1-85320 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunocytochemistry/Immunofluorescence: DACH1 Antibody [NBP1-85320] - Staining of human cell line A-431 shows localization to nucleoplasm & vesicles.

DACH1 Antibody - 26730002 from Novus Biologicals

Prices	$429.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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