Ifnl3

Gene Symbol Ifnl3
Entrez Gene 338374
Alt Symbol IFL-1, IL-28B, INF-alpha, INF-lambda, Il28, Il28b
Species Mouse
Gene Type protein-coding
Description interferon lambda 3
Other Description IFN-lambda-3|interferon alpha|interferon lambda-3|interleukin 28|interleukin 28B|interleukin-28B
Swissprots Q8CGK6 Q4VK73
Accessions Q8CGK6 AY184375 AAN86128 AY869696 AAX58715 BC140273 AAI40274 BC141644 AAI41645 XM_006540130 XP_006540193 NM_177396 NP_796370
Function Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express
Subcellular Location Secreted {ECO:0000250}.
Top Pathways Jak-STAT signaling pathway

Anti-IL28 Antibody (clone RN28) - LS-C107111 from LifeSpan Bioscience

Prices $225.00, $345.00
Sizes 50 µg, 500 µg
Host Rat
Clonality Monoclonal
Clone RN28
Standard curve of mouse IL-28 ELISA. Recombinant cytokine standard concentration in pg/ml.

Anti-IL28 Antibody (Biotin) - LS-C106976 from LifeSpan Bioscience

Prices $235.00, $365.00
Sizes 50 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Standard curve of mouse IL-28 ELISA. Recombinant cytokine standard concentration in pg/ml.

IL-28A/B (IFN-lambda 2/3) Antibody (244716) [Unconjugated] - MAB17892 from Novus Biologicals

Prices $99.00, $269.00, $699.00
Sizes 25 µg, 100 µg, 500 µg
Host Rat
Clonality Monoclonal
Clone 244716
Recombinant Mouse IL‑28B/IFN‑ lambda 3 (Catalog # 1789‑ML) reduces the Encephalomyocarditis Virus (EMCV)-induced cytopathy in the HepG2 human hepatocellular carcinoma cell line in a dose-dependent manner (orange line). Inhibition of EMCV activity elicited by Recombinant Mouse IL‑28B/IFN‑ lambda 3 (400 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse IL‑28B/IFN‑ lambda 3 Monoclonal Antibody (Catalog # MAB17892). The ND50 is typically 3-9 µg/mL.

IL-28B/IFN-lambda 3 Antibody - AF1789 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal

IL-28B/IFN-lambda 3 Antibody (RM0271-23A14) - NBP2-11706 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone RM0271-23A14

IL28 Antibody (RN28) - NBP2-00455 from Novus Biologicals

Prices $249.00, $369.00
Sizes 50 µg, 500 µg
Host Rat
Clonality Monoclonal
Clone RN28
ELISA: IL28 Antibody (RN28) [NBP2-00455] - Standard curve of mouse IL-28 ELISA.

IL-28B/IFN-lambda 3 Antibody [Biotin] - BAF1789 from Novus Biologicals

Host Goat
Clonality Polyclonal

IL28 Antibody [Biotin] - NBP2-00456 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
ELISA: IL28 Antibody [Biotin] [NBP2-00456] - Standard curve of mouse IL-28 ELISA

IFN alpha antibody - GTX59888 from GeneTex

Prices $319.00
Sizes 100 μl
Host Rabbit
Clonality Polyclonal

IL28B antibody [23A14] - GTX53362 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rat
Clonality Monoclonal
Clone 23A14

IFN alpha antibody - 10R-I139b from Fitzgerald

Prices $695.00
Sizes 250 µg
Host Rat
Clonality Monoclonal
Clone RMMA-1

IL28 antibody - 10R-6642 from Fitzgerald

Prices $140.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Clone RN28

IFN alpha antibody - 70R-12385 from Fitzgerald

Prices $355.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti -Interferon alpha (BSA, Glycerol Free) (IFNa) - I7662-02A1 from USBiological Life Science

Host Rat
Clonality Monoclonal
Clone 6A565

Anti -Interferon alpha (IFNa) - I7662-07 from USBiological Life Science

Host Rat
Clonality Monoclonal
Clone 8.S.088

Anti -Interferon alpha (IFNa) - I7662-02 from USBiological Life Science

Host Rat
Clonality Monoclonal
Clone 3H2484

Anti -Interferon alpha (IFNa) - I7662-02A from USBiological Life Science

Host Rat
Clonality Monoclonal
Clone 6A565

Anti -Interferon alpha (IFNa) - 138053 from USBiological Life Science

Host Rat
Clonality Monoclonal
Clone 13H291

Anti -Interleukin 28B (IL-28B) - 216705 from USBiological Life Science

Host Rat
Clonality Monoclonal
Clone 14L609

IFN alpha antibody - 20-IR86 from Fitzgerald

Host Rabbit
Clonality Polyclonal

IFN alpha antibody - 20R-1829 from Fitzgerald

Prices $595.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

IL28, Polyclonal Antibody - MBS625928 from MyBioSource

Prices $550.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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