Ifnl3

Gene Symbol	Ifnl3
Entrez Gene	338374
Alt Symbol	IFL-1, IL-28B, INF-alpha, INF-lambda, Il28, Il28b
Species	Mouse
Gene Type	protein-coding
Description	interferon lambda 3
Other Description	IFN-lambda-3|interferon alpha|interferon lambda-3|interleukin 28|interleukin 28B|interleukin-28B
Swissprots	Q8CGK6 Q4VK73
Accessions	Q8CGK6 AY184375 AAN86128 AY869696 AAX58715 BC140273 AAI40274 BC141644 AAI41645 XM_006540130 XP_006540193 NM_177396 NP_796370
Function	Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express
Subcellular Location	Secreted {ECO:0000250}.
Top Pathways	Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Recombinant Mouse IL-28B/IFN-lambda 3 Protein - NBP2-35077 from Novus Biologicals Category Protein Prices $69.00, $169.00, $2,669.00 Sizes 5 µg, 20 µg, 1 mg Source E. coli

Recombinant Mouse IL-28B/IFN-lambda 3 - 1789-ML-025 from R&D Systems Category Protein Source E. coli-derived, Asp20-Val193, with an N-terminal Met

Recombinant Mouse IL-28B/IFN-lambda 3, CF - 1789-ML-025/CF from R&D Systems Category Protein Source E. coli-derived, Asp20-Val193, with an N-terminal Met

Mouse IFN-lambda-3 (His Tag) protein - orb179811 from Biorbyt Category Protein Prices $255.00, $612.00 Sizes 20 μg, 50 μg Source Human Cells Species Mouse

IL 28B Mouse - CYPS-739 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Mouse

Recombinant Mouse Ifnl3, Met-tagged - Ifnl3-860M from Creative Biomart Category Protein Source E. coli Species Mouse

Recombinant Mouse Ifnl3, His and MBP-tagged - Ifnl3-19M from Creative Biomart Category Protein Source E. coli Species Mouse

Recombinant Mouse IL28B - IL28B-65M from Creative Biomart Category Protein Source E.coli Species Mouse

Recombinant Mouse Interleukin 28B, His-tag, MBP-tag - IL28B-214M from Creative Biomart Category Protein Source E. coli

Recombinant Mouse Interleukin 28B - Il28b-212M from Creative Biomart Category Protein Source DNA expressed in E.Coli.

Recombinant Mouse Interleukin 28B, Carrier Free - Il28b-213M from Creative Biomart Category Protein Source DNA expressed in E.Coli .

Mouse IL-28B / IFN-lambda-3 Protein (His Tag) - 51306-M08H-20 from Sino Biological Category Protein Prices $138.00, $298.00 Sizes 20 µg, 50 µg Source Human Cells Species Mouse

IL-28 A (IFN-Lambda 2) - PPE-45093 from Nordic BioSite Category Protein Species Mouse

Recombinant Mouse Interleukin-28B(Il28b) - CSB-YP807507MO CSB-EP807507MO CSB-BP807507MO CSB-MP807507MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

Recombinant Mouse IL-28B/IFN-lambda 3 Protein - 1789-ML from R&D Systems Category Protein Prices $329.00 Sizes 25 µg Source E. coli -derived Asp20-Val193, with an N-terminal Met Species Mouse

Recombinant Mouse IL-28B/IFN-lambda 3 Protein, CF - 1789-ML/CF from R&D Systems Category Protein Prices $329.00 Sizes 25 µg Source E. coli -derived Asp20-Val193, with an N-terminal Met Species Mouse

Recombinant Mouse IL28B Protein - IL28B-8163M from Creative Biomart Category Protein Source Mammalian Cells Species Mouse

Interleukin-28B Protein (Recombinant) - abx261676 from Abbexa Category Protein Species Mouse

Interleukin-28B, Mouse Recombinant - 228-20227-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Mouse

Recombinant Interferon Alpha (IFNa) - RPU52967 from Biomatik Category Protein Prices $194.00, $396.00, $605.00, $721.60 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Mouse

Mouse IL-28B / IFN-lambda-3 Protein (His Tag) - 51306-M08H from ABclonal Category Protein Prices $138.00, $298.00 Sizes 20 µg, 50 µg Source Human Cells Species Mouse

Recombinant Mouse INTERFERON ALPHA - 229-20289 from RayBiotech Category Protein Species Mouse

Interleukin-28B, Recombinant Protein - MBS146003 from MyBioSource Category Protein Prices $140.00, $205.00, $2,665.00 Sizes 5 µg, 20 µg, 1 mg Source E Coli

Interleukin-28B (Il28b), Recombinant Protein - MBS1475426 from MyBioSource Category Protein Prices $920.00, $920.00, $1,140.00, $1,140.00, $1,365.00, $1,365.00, $1,820.00, $1,820.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Mouse

Active Interferon Alpha (IFNa) - RPU54851 from Biomatik Category Protein Prices $810.00, $1,008.00, $3,780.00 Sizes 50 µg, 100 µg, 1 mg Source 293F cell Species Mouse

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