Ifnl3

Gene Symbol	Ifnl3
Entrez Gene	338374
Alt Symbol	IFL-1, IL-28B, INF-alpha, INF-lambda, Il28, Il28b
Species	Mouse
Gene Type	protein-coding
Description	interferon lambda 3
Other Description	IFN-lambda-3|interferon alpha|interferon lambda-3|interleukin 28|interleukin 28B|interleukin-28B
Swissprots	Q8CGK6 Q4VK73
Accessions	Q8CGK6 AY184375 AAN86128 AY869696 AAX58715 BC140273 AAI40274 BC141644 AAI41645 XM_006540130 XP_006540193 NM_177396 NP_796370
Function	Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express
Subcellular Location	Secreted {ECO:0000250}.
Top Pathways	Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IL-28 (Interleukin-28) Mouse ELISA Kit - ab100708 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 2 pg/ml Range 2.46 pg/ml - 600 pg/ml

Mouse IL28 ELISA Kit (Sandwich ELISA) - LS-F539 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 2.458 pg/ml Range 2.458-240 pg/ml

Mouse IL28 ELISA Kit (Sandwich ELISA) - LS-F1018 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 2.458-240 pg/ml

Mouse IL-28 ELISA Kit - RAB0292 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Interferon Alpha Antibody (IFN Ab) BioAssay™ ELISA Kit (Mouse) - 195038 from USBiological Life Science Category ELISA Kit Sensitivity 1.0ng/mL Range 2.5-50ng/mL

Interleukin 28 (IL-28), Mouse, ELISA Kit - CSB-E15986m from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

Interleukin-28B, Il28b, Mouse, ELISA Kit - E2028m from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Il28b (Mouse) ELISA Kit - KA1796 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

Interferon alpha, ELISA Kit - MBS039736 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/ml. Range 3.12 pg/ml - 100 pg/ml.

Mouse IL-28 ELISA Kit - GWB-SKR187 from Genway Biotech Category ELISA Kit Prices $520.00 Sizes 96 tests Sensitivity 32 pg/mL Range 32-4000 pg/ml

Mouse Interferon alpha ELISA Kit - DEIA9650 from Creative Diagnostics Category ELISA Kit Range 12.5-400 pg/mL

Mouse IL-28 ELISA Kit - DEIA5559 from Creative Diagnostics Category ELISA Kit Sensitivity 2 pg/mL

Mouse IL-28 ELISA Kit - DEIA8361 from Creative Diagnostics Category ELISA Kit

Interleukin 27, IL-27, ELISA Kit - MBS9303729 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

interleukin 28B (interferon, lambda 3) , ELISA Kit - MBS705625 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

Mouse IL-28 Platinum ELISA - BMS6028* from eBioscience Prices $429.00, $2,149.00 Sizes 96 tests, 10 x 96 tests Sensitivity 12.85 pg/mL Range 31.3 - 2000 pg/mL

Mouse Interleukin 28(IL-28) ELISA Kit - CSB-E15986m from Cusabio Category ELISA Kit Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

Mouse Interferon Alpha (IFNa) ELISA Kit - EKU05075 from Biomatik Category ELISA Kit Prices $529.00, $2,355.00, $4,287.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 6.0 pg/mL Range 15.6-1000 pg/mL

Mouse Interferon alpha ELISA Kit - abx051096 from Abbexa Category ELISA Kit Sensitivity 0.5 pg/ml Range 3 pg/ml - 200 pg/ml

Mouse Interferon Alpha ELISA Kit - abx154226 from Abbexa Category ELISA Kit Range 15.63 pg/ml - 1000 pg/ml

Mouse Interferon Alpha CLIA Kit - abx190512 from Abbexa Category CLIA Kit Range 2.74 pg/ml - 2000 pg/ml

Mouse IFN-alpha 2 ELISA Kit - CK2010-1 from Cell Science Category ELISA Kit Prices $670.00 Sizes 1 plate

Mouse IFN-alpha 2 ELISA Kit - CK2010-5 from Cell Science Category ELISA Kit Prices $2,795.00 Sizes 5 plates

Mouse IL28 ELISA kit - orb79049 from Biorbyt Category ELISA Kit Prices $765.00, $1,292.00, $2,754.00 Sizes 96 well, 192 assays, 480 assays

Mouse Interferon Alpha (IFNa) ELISA Kit (CLIA) - EKU72222 from Biomatik Category ELISA Kit Prices $907.20, $3,991.68, $7,257.60 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 1.16pg/mL Range 2.74-2000pg/mL The standard curve concentrations used for the CLIA’s were 2000pg/mL, 666.67pg/mL, 222.22pg/mL, 74.07pg/mL, 24.69pg/mL, 8.23pg/mL, 2.74pg/mL

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