| Gene Symbol |
Ifnl3
|
| Entrez Gene |
338374
|
| Alt Symbol |
IFL-1, IL-28B, INF-alpha, INF-lambda, Il28, Il28b
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
interferon lambda 3
|
| Other Description |
IFN-lambda-3|interferon alpha|interferon lambda-3|interleukin 28|interleukin 28B|interleukin-28B
|
| Swissprots |
Q8CGK6 Q4VK73
|
| Accessions |
Q8CGK6 AY184375 AAN86128 AY869696 AAX58715 BC140273 AAI40274 BC141644 AAI41645 XM_006540130 XP_006540193 NM_177396 NP_796370
|
| Function |
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express
|
| Subcellular Location |
Secreted {ECO:0000250}.
|
| Top Pathways |
Jak-STAT signaling pathway
|