| Gene Symbol | Ifnl3 |
|---|---|
| Entrez Gene | 338374 |
| Alt Symbol | IFL-1, IL-28B, INF-alpha, INF-lambda, Il28, Il28b |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | interferon lambda 3 |
| Other Description | IFN-lambda-3|interferon alpha|interferon lambda-3|interleukin 28|interleukin 28B|interleukin-28B |
| Swissprots | Q8CGK6 Q4VK73 |
| Accessions | Q8CGK6 AY184375 AAN86128 AY869696 AAX58715 BC140273 AAI40274 BC141644 AAI41645 XM_006540130 XP_006540193 NM_177396 NP_796370 |
| Function | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express |
| Subcellular Location | Secreted {ECO:0000250}. |
| Top Pathways | Jak-STAT signaling pathway |
IL-28B siRNA (m) - sc-45665 from Santa Cruz Biotechnology
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IL-28B shRNA Plasmid (m) - sc-45665-SH from Santa Cruz Biotechnology
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IL-28B shRNA (m) Lentiviral Particles - sc-45665-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN33789 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33789 from Sigma-Aldrich
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IFNL3 siRNA (Mouse) - CRN4724 from Cohesion Biosciences
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IFNL3 - MBS8231924 from MyBioSource
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shRNA set against Mouse IL28B (NM_177396.1) - SHH318833 from Creative biogene
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Mouse IFNL3 siRNA - orb294199 from Biorbyt
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IFNL3 shRNA Plasmid (Mouse) - CHN4724 from Cohesion Biosciences
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IL28B miRNA 3'UTR clone - MiUTR1M-06008 from Creative biogene
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