| Gene Symbol |
KIN
|
| Entrez Gene |
22944
|
| Alt Symbol |
BTCD, KIN17, Rts2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Kin17 DNA and RNA binding protein
|
| Other Description |
DNA/RNA-binding protein KIN17|KIN, antigenic determinant of recA protein homolog|binding to curved DNA
|
| Swissprots |
O60870 B4DX32
|
| Accessions |
EAW86374 O60870 AA768850 AJ005273 CAA06462 AK296637 BAH12407 AK301789 BAG63244 AK309059 BC017309 AAH17309 BC037913 BX504040 XM_006717434 XP_006717497 XM_006717435 XP_006717498 XM_011519427 XP_011517729 XR_930485 NM_012311 NP_036443 NR_045609 NR_045610
|
| Function |
Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro. {ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485, ECO:0000269|PubMed:17045609}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485}. Cytoplasm {ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485}. Note=During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids. {ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485}.
|
| Tissue Specificity |
Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at protein level). {ECO:0000269|PubMed:10964102, ECO:0000269|PubMed:9266022}.
|