| Gene Symbol | KIN |
|---|---|
| Entrez Gene | 22944 |
| Alt Symbol | BTCD, KIN17, Rts2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Kin17 DNA and RNA binding protein |
| Other Description | DNA/RNA-binding protein KIN17|KIN, antigenic determinant of recA protein homolog|binding to curved DNA |
| Swissprots | O60870 B4DX32 |
| Accessions | EAW86374 O60870 AA768850 AJ005273 CAA06462 AK296637 BAH12407 AK301789 BAG63244 AK309059 BC017309 AAH17309 BC037913 BX504040 XM_006717434 XP_006717497 XM_006717435 XP_006717498 XM_011519427 XP_011517729 XR_930485 NM_012311 NP_036443 NR_045609 NR_045610 |
| Function | Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro. {ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485, ECO:0000269|PubMed:17045609}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485}. Cytoplasm {ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485}. Note=During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids. {ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485}. |
| Tissue Specificity | Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at protein level). {ECO:0000269|PubMed:10964102, ECO:0000269|PubMed:9266022}. |
KIN17 CRISPR/Cas9 KO Plasmid (h) - sc-406068 from Santa Cruz Biotechnology
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KIN17 HDR Plasmid (h) - sc-406068-HDR from Santa Cruz Biotechnology
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KIN17 Double Nickase Plasmid (h) - sc-406068-NIC from Santa Cruz Biotechnology
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KIN17 Double Nickase Plasmid (h2) - sc-406068-NIC-2 from Santa Cruz Biotechnology
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KIN17 CRISPR Activation Plasmid (h) - sc-406068-ACT from Santa Cruz Biotechnology
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KIN17 CRISPR Activation Plasmid (h2) - sc-406068-ACT-2 from Santa Cruz Biotechnology
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KIN17 Lentiviral Activation Particles (h) - sc-406068-LAC from Santa Cruz Biotechnology
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KIN17 Lentiviral Activation Particles (h2) - sc-406068-LAC-2 from Santa Cruz Biotechnology
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KIN17 siRNA (h) - sc-45958 from Santa Cruz Biotechnology
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KIN17 shRNA Plasmid (h) - sc-45958-SH from Santa Cruz Biotechnology
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KIN17 shRNA (h) Lentiviral Particles - sc-45958-V from Santa Cruz Biotechnology
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KIN RNAi - H00022944-R01 from Novus Biologicals
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MISSION® esiRNA - EHU138951 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11215 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11215 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06062 from Sigma-Aldrich
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KIN siRNA (Human) - CRH7891 from Cohesion Biosciences
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shRNA set against Human KIN (NM_012311.3) - SHH325467 from Creative biogene
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Human KIN siRNA - orb268393 from Biorbyt
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KIN shRNA Plasmid (Human) - CHH7891 from Cohesion Biosciences
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KIN miRNA 3'UTR clone - MiUTR3H-04346 from Creative biogene
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