KIN

Gene Symbol	KIN
Entrez Gene	22944
Alt Symbol	BTCD, KIN17, Rts2
Species	Human
Gene Type	protein-coding
Description	Kin17 DNA and RNA binding protein
Other Description	DNA/RNA-binding protein KIN17|KIN, antigenic determinant of recA protein homolog|binding to curved DNA
Swissprots	O60870 B4DX32
Accessions	EAW86374 O60870 AA768850 AJ005273 CAA06462 AK296637 BAH12407 AK301789 BAG63244 AK309059 BC017309 AAH17309 BC037913 BX504040 XM_006717434 XP_006717497 XM_006717435 XP_006717498 XM_011519427 XP_011517729 XR_930485 NM_012311 NP_036443 NR_045609 NR_045610
Function	Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro. {ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485, ECO:0000269|PubMed:17045609}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485}. Cytoplasm {ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485}. Note=During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids. {ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485}.
Tissue Specificity	Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at protein level). {ECO:0000269|PubMed:10964102, ECO:0000269|PubMed:9266022}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KIN full length protein - ab137170 from Abcam Category Protein Source E. coli Species Human

KIN17 / KIN Antibody Blocking Peptide - LS-E11290 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KIN17 / KIN Antibody Blocking Peptide - LS-E11075 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KIN Recombinant Protein - H00022944-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human KIN Protein - NBP2-23174 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

Human KIN protein - orb168698 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

K39 protein (His tag) - 80-1343 from Fitzgerald Category Protein Prices $95.00, $595.00 Sizes 100 µg, 1 mg Source E.coli

K39 protein (His tag) (biotin) - 80-1344 from Fitzgerald Category Protein Prices $195.00, $945.00 Sizes 100 µg, 1 mg Source E.coli

KIN17 protein (His tag) - 80R-2575 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

KIN (1-393, His-tag) - AR50621PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

KIN (1-393, His-tag) - AR50621PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

KIN - H00022944-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

KIN17, 1-393aa, Human, His tag, E.coli - 01-P1797 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

KIN fusion protein - Ag20396 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

KIN fusion protein - ag2963 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

KIN Human - PRPS-1282 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human KIN, His-tagged - KIN-384H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human KIN, antigenic determinant of recA protein homolog (mouse), His-tagged - KIN-358H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human DNA/RNA-binding protein KIN17(KIN) - CSB-YP012351HU CSB-EP012351HU CSB-BP012351HU CSB-MP012351HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

KIN17, 1-393aa, Human, His tag, E.coli - ATGP1797 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

KIN - TP305689 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

KIN Peptide, Human - M34GP08213H from Creative Peptides Category Peptide Source Synthetic. Species Human

KIN17 - PAT-81798-1 from Nordic BioSite Category Protein Species Human

KIN17 - PAT-81798-2 from Nordic BioSite Category Protein Species Human

KIN, Human Recombinant - 228-21381-1 from RayBiotech Category Protein Species Human

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