KIN

Gene Symbol	KIN
Entrez Gene	22944
Alt Symbol	BTCD, KIN17, Rts2
Species	Human
Gene Type	protein-coding
Description	Kin17 DNA and RNA binding protein
Other Description	DNA/RNA-binding protein KIN17\|KIN, antigenic determinant of recA protein homolog\|binding to curved DNA
Swissprots	O60870 B4DX32
Accessions	EAW86374 O60870 AA768850 AJ005273 CAA06462 AK296637 BAH12407 AK301789 BAG63244 AK309059 BC017309 AAH17309 BC037913 BX504040 XM_006717434 XP_006717497 XM_006717435 XP_006717498 XM_011519427 XP_011517729 XR_930485 NM_012311 NP_036443 NR_045609 NR_045610
Function	Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro. {ECO:0000250\|UniProtKB:Q8K339, ECO:0000269\|PubMed:11880372, ECO:0000269\|PubMed:12359749, ECO:0000269\|PubMed:12754299, ECO:0000269\|PubMed:12853634, ECO:0000269\|PubMed:15831485, ECO:0000269\|PubMed:17045609}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:11880372, ECO:0000269\|PubMed:12359749, ECO:0000269\|PubMed:12754299, ECO:0000269\|PubMed:12853634, ECO:0000269\|PubMed:15831485}. Cytoplasm {ECO:0000269\|PubMed:11880372, ECO:0000269\|PubMed:12359749, ECO:0000269\|PubMed:12754299, ECO:0000269\|PubMed:12853634, ECO:0000269\|PubMed:15831485}. Note=During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids. {ECO:0000250\|UniProtKB:Q8K339, ECO:0000269\|PubMed:11880372, ECO:0000269\|PubMed:12359749, ECO:0000269\|PubMed:12754299, ECO:0000269\|PubMed:12853634, ECO:0000269\|PubMed:15831485}.
Tissue Specificity	Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at protein level). {ECO:0000269\|PubMed:10964102, ECO:0000269\|PubMed:9266022}.

KIN17 (F-5) - sc-271753 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

KIN17 (F-5): sc-271753. Western blot analysis of KIN17 expression in Jurkat whole cell lysate.

KIN17 (C-16) - sc-26955 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

KIN17 (C-16): sc-26955. Western blot analysis of KIN17 expression in Jurkat whole cell lysate.

KIN17 (H-65) - sc-98851 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

KIN17 (H-65): sc-98851. Western blot analysis of KIN17 expression in RKO (A) and HCT 116 (B) whole cell lysates.

KIN17 (K36) - sc-32768 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

KIN17 (K36) PE: sc-32768 PE. Intracellular FCM analysis of fixed and permeabilized K-562 cells. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2866.

KIN17 (K58) - sc-32769 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

KIN17 (K58): sc-32769. Immunofluorescence staining of methanol-fixed K-562 cells showing nuclear localization.

Anti-KIN antibody - ab22842 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KIN antibody (ab22842) at 1 µg/ml + HepG2 cell lysate with 5% skim milk / PBS bufferSecondaryHRP conjugated anti-Rabbit IgG diluted in 1: 50,000 - 100,025.Performed under reducing conditions.

Anti-KIN antibody - ab56222 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-KIN antibody (ab56222) at 2.5 µg/mlLane 1 : MarkerLane 2 : Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-KIN antibody [2490D1a] - ab67100 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2490D1a

Anti-KIN antibody [2490D1a] (ab67100) + immunising recombinant fragment

Anti-KIN antibody - N-terminal - ab191015 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-KIN antibody - N-terminal (ab191015) at 0.5 µg/mlLane 1 : Rat skeletal muscle lysateLane 2 : Human placenta lysateLane 3 : Rat testis lysate

Anti-KIN17 / KIN Antibody (clone 2490D1a) - LS-C184629 from LifeSpan Bioscience

Prices	$335.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	2490D1a

Anti-KIN17 / KIN Antibody - LS-C71370 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal

Anti-KIN17 / KIN Antibody (aa166-215) - LS-C31838 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-KIN17 / KIN Antibody (aa48-64) - LS-C313337 from LifeSpan Bioscience

Prices	$305.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

WB of KIN17 / KIN antibody. Lane 1: Rat Skeletal Muscle Tissue Lysate. Lane 2: Human Placenta Tissue Lysate. Lane 3: Rat Testis Tissue Lysate.

Anti-KIN17 / KIN Antibody (clone 2490D1a) - LS-C342660 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2490D1a

Western blot analysis of immunized recombinant protein, using anti-KIN monoclonal antibody.

Anti-KIN17 / KIN Antibody (aa230-279) - LS-C29695 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

KIN antibody LS-C29695 was used in IHC to stain formalin-fixed, paraffin-embedded human spermatophore.

KIN Antibody - NBP2-33374 from Novus Biologicals

Prices	$139.00, $299.00
Sizes	20 µl, 100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: KIN Antibody [NBP2-33374] - WB Suggested Anti- Titration: 0.2-1 ug/ml, ELISA Titer: 1:2500, Positive Control: HepG2 cell lysate

Anti-KIN antibody produced in rabbit - AV32295 from Sigma-Aldrich

Prices	$267.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Cell Type: Jurkat (<B>Cat. No. AV32295</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 2.5 μg/mL in cell type Jurkat

Anti-KIN antibody produced in rabbit - AV31690 from Sigma-Aldrich

Prices	$347.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-KIN: <B>Cat. No. AV31690</B>: Immunohistochemistry of KIN in Human Spermatophore tissue with KIN antibody at 4-8 μg/mL.

KIN antibody - middle region (ARP31690_P050) - ARP31690_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

KIN antibody - middle region (ARP32295_T100) - ARP32295_T100 from Aviva Systems Biology

Prices	$229.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

KIN antibody, Internal - GTX77858 from GeneTex

Prices	$319.00
Sizes	50 μg
Host	Rabbit
Clonality	Polyclonal

KIN antibody - 10R-1594 from Fitzgerald

Prices	$190.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	2490D1a

KIN antibody - 70R-18129 from Fitzgerald

Prices	$375.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti -KIN (DNA/RNA-binding Protein KIN17, BTCD, KIN17) - 211646 from USBiological Life Science

Host	Rabbit
Clonality	Polyclonal

Anti -KIN (KIN, Antigenic Determinant of recA Protein Homolog, Protein KIN Homolog,Binding to Curved DNA) - K1773-75 from USBiological Life Science

Host	Mouse
Clonality	Monoclonal
Clone	8D117

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